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R Callivà

Publications and source records attributed to R Callivà.

3 recordsLinked to original sources
PubMed1991

Flecainide: evidence of non-linear kinetics.

The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.

Adult↗
PubMedDate not supplied

[Lysine acetyl salicylate. Clinical contribution and preliminary data].

In the general study of antipyretic products for children prone to febrile convulsions, the authors describe the results obtained administering, the rectal route, three different doses of lysine acetylsalicylate (20-30-40 mg/kg/b.w.) to 53 children with fever. The lower dose was often inadequate in these patients, who need a quick reduction of body temperature below 38 degrees C. The two higher doses were useful both in clinical and in statistical terms, without relevant differences between groups. A statistically significant inverse correlation between blood levels of salicylates and temperature was also shown. No undesirable side effects were observed. The authors conclude that ASL, by rectal route, has to be considered a drug of choice for this indication.

Administration, Rectal↗