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Biomedical subjects

R Cappelletti

Publications and source records attributed to R Cappelletti.

35 records · Page 2Linked to original sources
PubMed1979

Intercellular glycosaminoglycans in human cancer.

Intercellular glycosaminoglycans (GAGs) from various tissues were analyzed by cellulose acetate electrophoresis and enzymatic treatment with specific mucopolysaccharidases. Each tissue exhibits a particular composition of sulfate and unsulfated molecular species. Invariably, malignant human neoplasias and their metastases show striking variations in the electrophoretic pattern typical of the corresponding normal tissue. An absolute or relative increase in surface ChS A/C and HA seems to be a consistent feature of neoplastic transformation. On the other hand, the GAGs composition of benign noninfiltrative tumors does not vary greatly with respect to the original normal tissue.

Animals↗
PubMed1979

Selective exposure of mucopolysaccharides is involved in macrophage physiology.

Surface and intracellular mucopolysaccharides of guinea-pig peritoneal macrophages maintained in suspension and monolayer culture were studied. At least five classes of compound (hyaluronic acid, heparan sulfate, dermatan sulfate, chondroitin 4-sulfate and chondroitin 6-sulfate) were resolved and characterized by electrophoresis and enzymatic degradation. The results reported here suggest that modulation of mucopolysaccharide exposure is involved in macrophage physiology. The possible biological role of surface mucopolysaccharides in macrophage activity is discussed.

Animals↗
PubMed1978

Intercellular glycosaminoglycans in normal and neoplastic tissues.

Intercellular glycosaminoglycans have been isolated from normal and neoplastic mammalian tissues. They have been characterized by cellulose acetate electrophoresis and by chemical and enzymatic degradation. The electrophoretic pattern of the intercellular glycosaminoglycans is tissue specific. Furthermore, the electrophoretic patterns of all spontaneous neoplasias analyzed differ significantly from patterns obtained from the tissues of origin.

Animals↗
PubMed1975

New 2-methyldialkylammoniumalkylthio-4,p-substituted phenyl-3H-1,5-benzodiazepine iodides with antibacterial activity note I.

A series of 2-methyldialkylammoniumalkylthio-4,p-substituted phenyl-3H-1,5-benzodiazepine iodides has been synthesized. Some compounds showed high selective activity against Staph. aureus and Strep. pyogenes. The nature of the sustituents at the phenyl moiety bound to the 4-position of the 1,5-benzodiazepine ring is of decisive influence, wherease the length of the aliphatic chain and the modification of the cationic head are of minor importance for the activity. The most active compound, 2-methyldiethylammoniumethylthio-4,p-phenylthiophenyl-3H-1,5-benzodiazepine iodide (XXXVIII), was selected for further research.

Bacteria↗
PubMedDate not supplied

Electric nerve stimulation: analysis of two clinical cases of failed nerve electrolocation by using sheathed needles.

The aim of this work was to explain the reasons of two unsuccessful blocks of sciatic nerve even if anaesthetic solution was injected through insulated needle on elicited twitch. The clinical cases were two outpatients undergoing diagnostic arthroscopy of knee under anaesthetic block of sciatic and femoral nerves. In both patients, the muscular twitch appeared when the ischiatic bone was kept in unexpected touch with needle tip. In spite of the attempt to locate correctly the needle (the touch with bone means that the nerve is not in front of the needle tip), the injection of anaesthetic solution was unsuccessful. In clinical environment, when electroinsulated needles gathered total amount of administered current on the needle tip, it was not possible to elicit a twitch just at the moment of touch of the needle with the bone. Referred events disagree with some experimental works performed out of clinical environment, which found that total amount of administered current through an insulated needle gathers always in front of the tip. Our clinical observations seems to confirm an electrolocation mistake called "electrical shadow". The ability of sheathed needles to work as occasional capacitor due to the alternation of two conductor layers (needle shaft and tissue) and of a dielectric (coating material) can explain some missing electrolocations, as the appearance of electric fields within dielectric needle sheathing.

Ambulatory Surgical Procedures↗
PubMedDate not supplied

[Anesthesia and post-operative intensive care in 55 patients with heart valve disease at high surgical risk. Technics and analysis of results].

Anaesthetic and Postoperative intensive Care techniques employed in 55 successive high risk surgical patients with valvular heart disease are discussed. Whereas an anaesthetic standard procedure is well established. Postoperative cardio-respiratory therapy in ICU is singularly decided on the basis of the physiological signs measured. The cardio-respiratory monitoring system at work is explained in details and a special bedside estimation of pulmonary circulation morphology is outlined. In our opinion an individualized treatment causes the post-operative recovery time to be sharply reduced. The myocardial protection during ischemic cardiac arrest has a crucial influence on the early mortality: among patients treated with Breitschneider II cardioplegic solution the early mortality is 10,8% at the lower level of the mortality range exhibited by other outstanding surgical teams.

Anesthesia↗