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R Cariou

Publications and source records attributed to R Cariou.

26 records · Page 2Linked to original sources
PubMed1987

The lupus anticoagulant and its role in thrombosis.

The lupus anticoagulant is usually found in the plasma of patients with systemic lupus erythematosus. Lupus anticoagulants are antibodies to phospholipids and probably to phosphodiester-linked phosphate groups. A high frequency of thrombotic events in patients with lupus anticoagulant has been reported. Nevertheless the pathogenesis of thrombosis in these patients remains unknown. Endothelium which plays a key role in the antithrombogenic-thrombogenic balance could be a target for the lupus anticoagulant and alterations of some endothelial-cell functions could be responsible for the thrombotic events. The effects of the lupus anticoagulant on the phospholipids of the protein C-thrombomodulin complex may be important although evidence of such a reaction in vivo is awaited.

Autoantibodies↗
PubMed1986

[Circulating lupus-type anticoagulant, a risk factor for thrombosis by inhibition of protein C activation].

The lupus anticoagulant is a risk factor of thrombosis. The non thrombogenic endothelial surface could be a target for the lupus anticoagulant. We have investigated the effect of purified immunoglobulins G of five patients with LA on the thrombomodulin activity of cultured human endothelial cells from umbilical cord vein. The rate of activation of purified protein C (PC) (30 nM) by the endothelial cells in the presence of thrombin (0.1 U/dish) has been measured by hydrolysis of substrate S 2366. Activated PC has been 7.37 +/- 0.78 pmoles X ml-1 X h-1 in the presence of buffer and 7.2 +/- 0.78 pmoles X ml-1 X h-1 in the presence of control IgG (2 mg/dish). Heat aggregated IgG did not induce any significant change. Patient's IgG lowered significantly the rate of PC activation (4.86 +/- 1.04 pmoles X ml-1 X h-1, p less than 0.001). Fab fragment from two of these patient's IgG displayed the same inhibition. Moreover neutralization of this effect was obtained by addition of phospholipids (70% phosphatidylcholine, 30% phosphatidylserine) in excess to patient's IgG. Activation of PC has been also performed using purified rabbit thrombomodulin and a similar inhibition by patient's IgG was found. These results seem to indicate that antibodies present in the IgG fractions containing LA could be directed against phospholipids associated to thrombomodulin activity. Reduction of PC activation if present in the patients with LA could play a role in the occurrence of thrombosis.

Animals↗
PubMed1986

[Osteomedullary amyloidosis with osteolytic lesions. Apropos of 4 cases].

Amyloidosis of bone and bone marrow is rarely symptomatic and is generally limited to deposits diagnosed by histological examination. Four cases with lytic bone lesions are reported. In 2 cases, amyloidosis was associated with Waldenstroem's Macroglobulinemia, in one case with multiple myeloma and in 1 case with solitary plasmocytoma. These 4 cases are compared to 14 cases already published in the literature, including 2 cases of plasmocytic dyscrasias. The role of amyloidosis in the genesis of bone lesions is discussed.

Aged↗
PubMed1985

Interleukin 2 production by peripheral blood lymphocytes in allograft recipients during acute rejection episodes.

In this study we investigate the relationship between the Interleukin 2 (IL-2) yield produced by kidney allograft recipient's peripheral blood lymphocytes (PBL) under lectin stimulation and the occurrence of acute rejection episodes. PBL were harvested prospectively before grafting, after grafting in steady-state period, and at the onset of acute rejection episodes. In addition, we tested retrospectively the ability of PBL of recipients engrafted for more than 1 yr to produce IL-2. IL-2 levels were assessed on the IL-2-dependent CTL-L2 murine cell line. Our data show: 1) before grafting, hemodialysed patients (N = 14) produced normal IL-2 yield compared with healthy donors (N = 21); 2) the IL-2 secretion of PBL of recipients with good graft function (N = 18) is decreased markedly during roughly the first 12 months following transplantation (P less than 0.01); 3) when acute rejection crisis occurred during this time period (N = 24), a sharp and highly significant increment (P less than 0.01) in lectin-induced IL-2 production of recipient's PBL was seen. After 1 yr, the capacity to secrete IL-2 upon lectin stimulation tends to be restored. Finally, our data correlate rejection and high PBL-IL-2 secretion clearly at a time when recipients with well-functioning grafts have markedly impaired IL-2 secretion.

Graft Rejection↗
PubMed1985

[Chromosome 3 abnormalities with dysmegakaryocytopoiesis in in subacute transformation in chronic myeloid leukemia].

A patient with Ph1 positive chronic myeloid leukemia developed accelerated phase with cytological abnormalities of platelets and megakaryocytes, and persistence of a high platelet count, after the failure of a course of intensive chemotherapy. During this phase, the karyotype analysis revealed two different Ph1 positive clones: one with a pericentric inversion of chromosome 3, the other with the same abnormality and a paracentric inversion of the second chromosome 3. Cases of acute leukemia with normal thrombopoiesis and abnormalities of chromosome 3, especially paracentric inversion, have already been reported. The significance of this association is discussed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

Increased interleukin II production during kidney allograft rejection.

We have studied the lectin-induced production of Interleukin II (IL-2) by peripheral blood leucocytes (PBL) obtained from recipients of kidney grafts. Pre-graft values (haemodialysed patients) are similar to those of healthy individuals. After grafting and during the first year the IL-2 levels produced by PBL from recipients with well functioning grafts are very low (p less than 0.001). Years after grafting the IL-2 yields tend towards restoration. At the onset of an acute rejection the IL-2 production rises significantly. These data show that an increase in IL-2 production may play a role in the rejection process.

Graft Rejection↗
PubMed1982

[Is annual X-ray examination of the chest still justified in industrial medicine?].

Between 1975 and 1979, 137.526 annual X-ray examinations of the chest were performed among the employees of a large Paris administration. Fifty-four cases of tuberculosis, 28 cases of sarcoidosis, 10 cases of bronchial carcinoma and 26 miscellaneous chest diseases were detected. This study confirms the inadequacy of radiological examination for detecting chronic obstructive bronchopulmonary conditions. The small proportion of tuberculosis (0.39 p.1000) and bronchial carcinoma (0.07 p.1000) revealed by this method suggests that it should be reserved to high risk patients.

Carcinoma, Bronchogenic↗