Glial choristoma of the tongue: report of a case.
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Biomedical subjects
Publications and source records attributed to R Carrillo.
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In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (> 5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.
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Nucleolar organizer regions (NOR) were studied in 15 salivary gland myoepitheliomas by an argyrophilic staining technic (AgNOR). The AgNOR data were then compared with flow cytometric DNA content of the neoplasms and also with selected clinicopathologic parameters. We conclude that AgNOR's: (1) do not correlate well with DNA cytometric indices and (2) at best, provide redundant information.
Haemangiopericytomas involving the parotid gland are uncommon and those arising from the gland itself are rare. Three examples of primary parotid gland hemangiopericytoma are presented. The biological course of parotid or periparotid haemangiopericytomas does not differ from that manifested by their counterparts arising from somatic soft tumours.
Springing from mesenchyme rather than mature synovial tissues, synovial sarcomas are high-grade neoplasms that express epithelial as well as supporting tissue features. Accordingly, their histologic phenotypes can be epithelial, stromal, or mixed. Between 3% and 10% of all synovial sarcomas originate in the head and neck, particularly from parapharyngeal sites. These is no appreciable difference in biologic activity between synovial sarcomas of the head and neck and those arising from other anatomic sites. Five-year survivals are misleadingly optimistic and do not adequately reflect the natural history of the sarcoma. Synovial sarcoma is known to metastasize late, and few patients survive that event.
A clinicopathologic study of five patients with Paget's disease of the jaws is reported. All patients had well-documented cases of osteitis deformans with polyostotic involvement. Histologic studies of facial bones could be performed because surgery was necessary for either cosmetic or functional reasons. Three specimens consisted of maxillary bone, and two were mandibular. Microscopically, all cases showed multiple and irregular fibroproliferative lesions containing mineralized structures intermingled with bone characteristic of Paget's disease. The purpose of this article is to present these fibro-osseous lesions in relation to Paget's disease of the jaws and to emphasize their close resemblance to other benign fibro-osseous lesions of the jaws, especially cementifying and ossifying fibroma, and florid osseous dysplasia.
The purpose of this study was to examine to what extent Mexican-American male and female psychiatric patients, who share similar DSM-III--R diagnoses, differ on the MMPI. Differences were found on the Infrequency, Masculinity-Femininity, and Paranoia scales, with the 39 men obtaining significantly higher scores than the 21 women. These results, while suggesting possible differences in the phenomenology of depression, also suggest that MMPI differences between Mexican-American men and women may be reflective of culturally-defined sex roles. These results, when taken within the context of Mexican-American MMPI literature, indicate that researchers should always attempt to account for "gender" when conducting cross-ethnic MMPI comparisons. The practice of grouping the MMPIs of Mexican-American men and women for comparison with other ethnic groups should be discontinued in favor of comparisons that consider the effects of gender and ethnicity.
We describe a fatal case of spontaneous necrotizing myositis due to a highly resistant strain of Serratia marcescens in a renal transplant recipient. Though Staphylococcus aureus and Clostridium are the usual agents which cause either pyomyositis or necrotizing myositis, gram-negative bacteria are a dangerous and rarely suspected possibility. Such an aggressive disease should be promptly recognized because immunosuppression in susceptible hosts makes conservative management unsuccessful. The prognosis for myositis in immunodepressed hosts is poor and wide excision of all the necrotic muscles, leaving the wound open, and intensive antibiotic therapy are required.
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Three cases of primary cutaneous neuroendocrine carcinoma involving the face are reported. In the first patient the tumor developed in the scar of a previously excised basal cell carcinoma of the nose, recurred locally, and metastasized to a regional lymph node 2 1/2 years after initial treatment. In the second and third patients the tumors were located on the forehead and were removed with a wide excision. In the second patient the tumor metastasized to regional lymph nodes 1 month after treatment. Light microscopic examination in all patients showed an undifferentiated, small cell, dermal tumor with prominent epidermotropism, forming Pautrier-like microabscesses. Immunohistochemical staining for neuron-specific enolase was positive, and ultrastructural examination revealed numerous cytoplasmic neurosecretory granules and paranuclear aggregates of intermediate-sized filaments. The literature concerning epidermal involvement by primary neuroendocrine carcinoma of the skin is reviewed; the relation with basal cell carcinoma and treatment are discussed.
Two children with spinal dermal sinuses of congenital origin are described. They are unusual because the skin dimples were located off the midline at the gluteal region.
A new case of hypothalamic hamartoma associated with precocious puberty is presented. After reviewing the literature, 23 other cases appeared. The ultrastructural study of the present case revealed common features with other hamartomatous lesions of the central nervous system and with the gangliogliomas. The data suggest that these lesions are morphologically organized in a very similar manner despite their very different growing potential.
Considerable variation in the frequency of the clinical manifestations of onchocerciasis was seen in the individual endemic foci of the disease in province of Esmeraldas, Ecuador. In hypoendemic areas, 84.6% of all microfilaria-positive inhabitants were found to be free of any clinical manifestations of the disease, whereas in the hyperendemic area clinical manifestations were present in 57.9% of those infected. Ocular keratitis, macular papular rash of the skin and subcutaneous onchocercal nodules of varying frequency were the major clinical variants. Long-standing onchodermatitis and hypertrophy of the skin were rarely seen. Clinical evidence of prolonged ocular and skin invasion by microfilariae was seen only in the hyperendemic area. Of the 26.1% of the microfilaria-positive inhabitants who had onchocercal nodules, 91.7% lived in the hyperendemic area. 41.1% of all nodules occurred in the region of the iliac crest. Clinical conditions associated with high microfilarial density, i.e., elephantiasis of the legs and scrotum, lymphadenopathy, hanging groin, hydrocele and inguinal hernia were seen only in the hyperendemic area. The clinical features were similar to those seen in Africa, but the low incidence of the clinical presentation and severity of the disease suggested a recent infestation of the province.
The frequency, intensity and clinical features of onchocerciasis in the two ethnic groups (Blacks and Chachilla--an indigenous tribe) in the endemic foci of the disease in Esmeraldas province (Ecuador) were evaluated. The incidence of infection and intensity of the disease seen in both groups were directly related to the frequency of man-vector contact and not to racial factors. Both groups showed the same rate of positivity in both the hyperendemic and hypoendemic areas. Males of both groups had a consistently higher positivity rate than did females. The Chachilla were found to have a higher mean microfilarial density than Blacks in both types of endemic areas. Certain clinical features of the disease analogous to those seen in the African form were present only in Blacks. No lymphatic involvement or hypertrophic scarring was seen in the Chachilla, suggesting that in the Blacks there may be a generaically related predisposition to lymphatic complications of microfilarial infections.
A rare case of an intracerebral schwannoma in a 10-year-old girl is presented. To our knowledge, only 4 cases of intracranial schwannoma not related to cranial nerves have been previously published, in the absence of von Recklinghausen's disease.
A case is presented of a child with an arteriovenous fistula and a giant aneurysm located beside the brain stem under the right temporal lobe. It was successfully treated by clipping its feeding artery, a branch of the right posterior cerebral artery. The similarities to, and the differences from, aneurysms of the vein of Galen are discussed.