PubMed Health⌕ Search

Biomedical subjects

R Caudarella

Publications and source records attributed to R Caudarella.

At least 19 recordsLinked to original sources
PubMed1991

Relationships between some lithogenetic factors and vitamin B6-status in idiopathic calcium lithiasis.

Several researchers have shown that a reduced intake of vitamin B6 can induce increased oxalate urinary excretion leading to a higher incidence of calcium oxalate stones. Furthermore, the treatment with pyridoxine in patients with urinary stones and high oxalate excretion has led to contradictory results as the excretion of oxalate was either decreased, unchanged or increased. To verify if these divergent results were linked to a different B6 status of the patients undergoing the treatment, we studied the vitamin B6 and the main lithogenetic factor levels in patients with idiopathic calcium lithiasis as compared to normal subjects. The results showed that a high oxalate excretion is not necessarily coupled with a low vitamin B6 status and viceversa. However, some stone formers present a non homogeneous vitamin pattern that could be the consequence of an abnormal vitamin B6 metabolism.

Calcium Oxalate↗
PubMed1986

Idiopathic calcium urolithiasis: genetic aspects.

Seventy-nine stone-formers underwent a metabolic investigation and ABO blood group determination. Incidence of blood groups in patients was similar to ABO phenotypes distribution in general population. The 37.7 p. 100 showed family history for stones. Idiopathic hypercalciuria was present in 40.3 p. 100 of cases; stone-formers with positive family history had a higher incidence of hypercalciuria (46.8 p. 100) than subjects without affected relatives (31.5 p. 100). Patients with blood group A displayed hypercalciuria in the 54.5 p. 100 of cases while subjects with blood group O only in the 30.7 p. 100 (p less than 0.05). Glycosaminoglycans (GAGs) were reduced in the 36.9 p. 100 of the whole group and particularly in patients of blood group A. Patients with blood group A, with positive family history, showed higher mean values of calcium excretion and lower ones of GAGs. Our results seem to suggest that not only familiar factors play a significant role in stone disease pathogenesis but also some metabolic alteration may be linked to ABO phenotypes.

ABO Blood-Group System↗
PubMed1979

[Functional respiratory and blood gas analytical studies of the effects of fenspiride, in oral and intramuscular administration, in chronic bronchopneumopathic subjects].

A group of 20 chronic bronchopneumopathics was treated for 15 days with fenspiride orally and i.m. The behaviour of a set of functional respiratory and haemogasanalytic parameters was monitored at various times (basic, 5th, 10th and 15th days). Progressive, significant improvements in VC, FEV1, RV and in related parameters were observed. These were attributed to the drug's anti-inflammatory effect in the respiratory ways as well as to its direct antibronchospastic action. Stress is laid on the excellent clinical tolerance of fenspiride following its oral and i.m. administration.

Adult↗
PubMed1979

[Effects of low frequency vibrations on the human spine].

There is a general agreement in literature about effects of low frequency vibrations on spine in tractor drivers. Tractor drivers are exposed to noxious vibrations transmitted mostly by the seat. Spine generally presents a picture of degenerative lesions with higher incidence than in control groups. A statistical relation to the precocity of tractor driving can be shown.

Humans↗
PubMed1977

[Electron microscopy features of renal changes in chronic lead poisoning (author's transl)].

The Authors report the results of a renal morphological study carried out on eight patients with chronic lead poisoning. The ultrastructural analysis showed changes, mainly involving the proximal tubules, as follows: 1) degenerative pattern (swollen mitochondria, dilated endoplasmic reticulum and scanty microvilli); 2) signs of metabolic hyperactivity (intranuclear granular inclusions, odd shaped nuclei); 3) regenerative pattern (poorly differentiated cells with few microvilli, shallow infoldings of basal cell membranes). In the glomeruli the most characteristic finding was a mesangial reaction. The basement membrane, in some cases, appeared to be thickened and the visceral epithelial cells hypertrophic. Interstitial fibrosis was present, as well as, occasionally, a certain degree of arteriolar hyperplasia. These data appear to confirm that chronic lead nephropathy has an extremely slow evolution.

Adult↗
PubMed1976

[Respiratory disease in foundry workers. An epidemiologic survey in three foundries (author's transl)].

The authors report the results of a survey performed in three cast iron foundries, with particular emphasis on the impairment of respiratory system in the involved workers. The results obtained showed a high prevalence of pneumoconiosis, which, as for roentgenologic and clinical features, appears to be different from usual silicotic pneumoconiosis. The highest prevalence of chronic bronchitis -- either associated or not with pneumoconiosis -- in the foundry workers examined is stressed, as well as the prevalence of squamous metaplasia of the bronchial epithelium. An important role in this aspect is supposed to be played not only by dusts, but even by tobacco smoke in favouring the onset of the above mentioned alterations is also confirmed.

Bronchitis↗
PubMed1975

[Histologic patterns of liver damage in chronic poisoning from tri-ortho-cresyl phosphate (author's transl)].

Six subjects, affected with TOCP polyneuritis, were submitted to liver biopsy by means of Menghini's technique. By means of both optic and electron microscopy, histologic and ultrastructural findings of liver damage were evaluated, whose genesis is believed to be due to the toxic effect of TOCP. The hepatocytes showed changes, mainly represented by cloud-vacuolar swelling of the cytoplasm, with abnormalities of nuclear membrane and lipofuscin pigment accumulation. The above mentioned patterns were found in all the examined needle biopsies, which possibly account for their toxic nature.

Cell Nucleus↗