Biomedical subjects

R Ceneviva

Publications and source records attributed to R Ceneviva.

At least 37 records · Page 2Linked to original sources

PubMed1987

Liver trophism in dogs made diabetic by total pancreatectomy or alloxan administration.

1. In order to evaluate hepatic trophism in diabetic dogs, an experimental study was carried out on 30 adult mongrel dogs of both sexes weighing 11.9 +/- 1.6 kg, divided into three groups: 1) Controls (C) (N = 10), submitted to partial (30%) hepatectomy; 2) PD Animals (N = 10), submitted to partial hepatectomy plus total pancreatectomy with preservation of the duodenum during the same surgical intervention; 3) and AD Animals (N = 10), submitted to partial and simultaneously made diabetic with alloxan. 2. The animals were submitted to an oral glucose tolerance test (OGTT) one day before and on the 7th day after partial hepatectomy to evaluate the severity of diabetes. During the post-hepatectomy period the fasting glycemia values were similar for both diabetic groups (greater than 200 mg%). During OGTT, blood glucose levels of the diabetic groups peaked at 60 min but were significantly higher for the AD than for the PD group. The difference persisted at 120 and 180 min, but was no longer statistically significant. 3. Liver trophism was evaluated by measuring liver RNA content and the nuclear volume of hepatocytes. Both diabetic groups showed significantly lower RNA contents and absence of nuclear hypertrophy compared to partially hepatectomized controls probably because of the severe diabetes induced in these animals.

Alloxan↗

PubMed1986

Simple suture with or without proximal gastric vagotomy for perforated duodenal ulcer.

To assess the results of proximal gastric vagotomy (PGV) in the definitive treatment of perforated duodenal ulcers, a prospective study was carried out comparing PGV in association with omental patch suture (PGV + S) with the simple omental patch suture procedure (S). The PGV + S series consisted of 38 consecutive patients with perforated duodenal ulcer and the S series consisted of 38 survivors of a similar series of 41 consecutive patients. Surgical mortality was zero in the PGV + S series. The patients were followed up for 1 to 7 years. No cases of dumping or diarrhoea were observed. Thirty-three patients in the PGV + S series (87 per cent) were classified as Visick grade I and only two (5 per cent) as Visick grade IV. In contrast, 11 patients (29 per cent) were Visick grade I and 22 (58 per cent) were Visick grade IV in the S series. Recurrent ulcer was detected endoscopically in 58 per cent of the patients who had been treated with simple suture and in only 5 per cent after suture plus PGV. PGV is a safe operation with a negligible morbidity rate and with a significant rate of effective control of ulcer disease. Depending on the general condition of the patient and on the surgeon's skill, it appears preferable to treat not only the acute perforation but also the ulcer disease by PGV.

Adult↗

PubMed1985

Lack of correlation between intragastric pressure and early gastric emptying rate after proximal gastric vagotomy.

In order to evaluate the contribution of the impairment of the gastric accommodation to distension to the abnormalities of the gastric emptying of a liquid meal, these functions were evaluated simultaneously in 20 duodenal ulcer patients after proximal gastric vagotomy and in 13 non-operated duodenal ulcer patients. Gastric accommodation was measured by recording intragastric pressure during intragastric instillation of 500 ml 10% dextrose and the gastric emptying of this solution was measured with the double-sample test meal with phenol red as unabsorbable marker. The intragastric volume remaining 10 min after the 500 ml 10% dextrose test meal was significantly (P less than 0.02) smaller in the post-vagotomy patients (range: 60.0 to 580.0 ml; median: 320.0 ml) than in the non-operated patients (range: 220.0 to 540.0 ml; median: 380.0 ml). There was no significant difference between the two groups for the half-life of the test meal in the stomach. Maximal intragastric pressure was significantly higher (P less than 0.02) in post-vagotomy patients (range: 3.3 to 14.5 mmHg; median: 8.7 mmHg) than in non-operated patients (range: 1.8 to 5.5 mmHg; median: 3.8 mmHg). There was no significant correlation between maximal intragastric pressure and volume remaining 10 min after the test meal or half-life values within any group. These results confirm other studies showing that the initial gastric emptying rate of a liquid meal is accelerated and the gastric accommodation to distension is impaired by proximal gastric vagotomy, while overall gastric emptying is not changed.(ABSTRACT TRUNCATED AT 250 WORDS)

Adaptation, Physiological↗

PubMed1984

The effect of a segmental gastrectomy with proximal gastric vagotomy on gastric secretion and gastric emptying.

Gastric acid secretory responses to graded doses of pentagastrin were measured in duodenal ulcer patients before and after either proximal gastric vagotomy (17 patients) or proximal gastric vagotomy associated with a segmental gastrectomy (11 patients). Calculated maximal output of acid and responsiveness of the acid-secreting cells to pentagastrin were reduced by both operations; after surgery, maximal acid output was lower in the proximal gastric vagotomy plus segmental gastrectomy group than in the proximal gastric vagotomy group. Gastric emptying of a liquid meal was assessed before and after either proximal vagotomy (13 patients) or proximal gastric vagotomy plus segmental gastrectomy (9 patients). The early phase of emptying was equally accelerated by both operations, and at later stages the emptying was only slightly, but not significantly, faster following proximal gastric vagotomy associated with segmental gastrectomy.

Adolescent↗

PubMed1984

Contribution of intraoperative biliary manometry for the diagnosis of bile duct stones.

Sixty patients with cholecystitis and gallstones, with and without biliary duct calculi, were submitted to intraoperative biliary manometry and cholangiography. The patients were subdivided into two groups of 30: Group A, without biliary duct calculi, and Group B, with biliary duct calculi. The pathology had been diagnosed before surgery for 24 patients in group B (B1), and for 6 (B2), diagnosis was made on the basis of intraoperative manometry which showed higher pressure values than those encountered in the main bile ducts of patients without calculi, and of intraoperative cholangiography. Choledocotomy, which was performed on all 6 patients, confirmed the presence of calculi. When three successive sequences of pressure measurements were performed on the common bile duct of patients with biliary duct stones there was an increase in pressure at 10, 15 and 20 s from the first compared to the third sequence. Intraoperative manometry suggested the presence of biliary duct calculi, which was confirmed by intraoperative cholangiography in the 20% of patients in group B for whom calculi had not been previously diagnosed, and decreased unnecessary choledocotomy.

Adolescent↗

PubMed1981