Biomedical subjects
R Cerundolo
Publications and source records attributed to R Cerundolo.
Dermatomyositis in five Shetland sheepdogs in the United Kingdom.
Five cases of dermatomyositis in four Shetland sheepdog puppies and one adult bitch are described. The dogs all had well-defined patches of scaling, crusting and alopecia over the muzzle, periorbital skin and distal limbs, and the tail, perineum and pinnae were affected in some of them. The affected puppies were all sired by the same stud dog. The affected adult bitch was unrelated to the puppies. Three of the four dogs tested had high serum creatine kinase concentrations and electromyographic abnormalities were detected in three of the four dogs tested. The histological changes observed in the skin of four of the dogs strongly supported the diagnosis of dermatomyositis, and in the fifth dog they were compatible with this diagnosis. Two of the puppies were euthanised shortly after being diagnosed. In the other two puppies and the adult the disease remains stable and non-progressive 15 to 18 months after diagnosis. The sire of the four affected puppies has been used extensively because it was considered to be genetically clear of collie eye anomaly.
Studies on the inheritance of hair loss in the Irish water spaniel.
The inheritance of hair loss in Irish water spaniels has been studied by evaluating the inbreeding levels and genetic relationships in a group of affected and unaffected dogs. A detailed study of the pedigree tree of four families revealed a familial predisposition suggesting a dominant mode of inheritance.
'Alopecia X' in chows, pomeranians and samoyeds.
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Preliminary report of infection in dogs related to Ehrlichia equi: description of three cases.
The clinical course of naturally infected dogs with E. equi are described. Fever (up to 41 degrees C), depression, dysorexia and ascites were observed. Laboratory findings revealed mild anemia, inclusion bodies within neutrophils in one dog, thrombocytopenia, hypoproteinemia, hypoalbuminemia and in two dogs hyperglobulinemia. In acute and convalescent dogs sera antibody titers from 1:60 to 1:480 to E. equi using IFA test were detected. Clinical resolution was obtained with long-term doxycycline monohydrate therapy.
Serological evidence of Ehrlichia canis in dogs in southern Italy.
A serological survey of antibodies to Ehrlichia canis was performed on 423 dogs. The indirect fluorescence antibody test was employed. For this purpose mouse-dog hybridoma cells infected with Ehrlichia canis were used. Eighty-five dogs were found positive. The study tested 25 dogs with clinical signs suggestive of a rickettsial infection. Twenty-three of them had antibodies to E. canis.
Vitiligo in two water buffaloes: histological, histochemical, and ultrastructural investigations.
Vitiligo, a skin disease, characterized by the spontaneous loss of melanin, has been described in several animals as well as in humans. Most of the reports of large domestic animals have dealt with clinical investigations without morphological data. In this report, the histological and ultrastructural characteristics of two cases of vitiligo in water buffaloes (Bubalus bubalis) are presented. Interestingly, many of the ultrastructural observations for vitiliginous buffaloes resemble those previously described for other species, e.g., humans, mouse, and chicken. These data suggest that one or more forms of human vitiligo may have a similar etiopathogenesis to that of the buffalo. Therefore, it is proposed that vitiliginous buffalo may prove to be a useful animal model for the human disease.
Animal models for lysosomal storage diseases: a new case of feline mucopolysaccharidosis VI.
Two long-haired Siamese cats are reported with clinical manifestations of human mucopolysaccharidosis VI (Maroteaux-Lamy disease): facial dysmorphia, dysostosis multiplex, paralysis. Urine of the two affected animals contained a high concentration of glycosaminoglycans, as detected by the dimethylmethylene blue test. Qualitative analysis, performed by thin-layer chromatography of the cetylpyridinium chloride-precipitable material, showed dermatan sulphate. Excessive incorporation of [35S]sulphate in the intracellular mucopolysaccharide of cultured fibroblasts and deficiency of arylsulphatase B in such cells indicate that these cats are affected by Maroteaux-Lamy disease. They should thus be considered the first European case of feline mucopolysaccharidosis VI.
Renal failure in bull terriers.
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