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Biomedical subjects

R Cerutti

Publications and source records attributed to R Cerutti.

At least 37 records · Page 2Linked to original sources
PubMed1988

Lumbar myelography with iopamidol: a methodological approach to the investigation of side effects.

Pathophysiology of adverse reactions occurring during myelography with non-ionic contrast agents, such as iopamidol, seem related to their direct action on the nervous system. The authors try a multivariate approach, involving neurophysiological, neuropsychological and neurochemical parameters on a pilot group of twelve subjects. Any possible change in the above examinations is thoroughly analyzed and correlated to the postulated neurotoxic properties of contrast media.

Central Nervous System Diseases↗
PubMed1987

Pharmacokinetics of co-trimazine after single and multiple doses.

Plasma and urinary levels of trimethoprim (TMP), sulfadiazine (SDZ) and N4-acetylsulfadiazine (N4-SDZ) were determined after administration of 1 g co-trimazine (equivalent to 180 mg TMP and 820 mg SDZ) (Kombinax) as a single dose and again once daily for 7 days to 6 normal subjects. Both TMP and SDZ were rapidly absorbed from the gastrointestinal tract with peak plasma levels being achieved within 4 h in all subjects. Elimination half-lives ranged from 8 to 13 h for TMP and from 9 to 15 h for SDZ. Approximately 50% of the administered dose of SDZ was recovered in urine within 24 h of the single dose (32% as unchanged drug and 17% as the N4-acetylmetabolite). For TMP, the urinary recovery during the 24 h following the single dose averaged 39%. Mean plasma levels of TMP, SDZ and N4-SDZ at steady state were moderately higher than those observed after a single dose, but no change in absorption or disposition kinetics of these compounds was seen after repeated dosing.

Adult↗
PubMed1987

Clinical pharmacokinetics and metabolism of pyrazinamide in healthy volunteers.

Eight healthy volunteers were treated with a single dose of pyrazinamide 35 mg/kg. The aim of the study was to evaluate the pharmacokinetic profile of the product and of its metabolites. Urine and blood samples were collected till the 60th h. The kinetics of pyrazinamide could be characterized as follows: CPmax = 50.1 micrograms/ml, tmax less than 1 h, t1/2 alpha = 3.2 h, t1/2 beta = 23 h, U(0-60 h) = 1.6% of the dose administered. The kinetics of the main metabolite, the pyrazinoic acid, gave the following values: CPmax = 66.6 micrograms/ml, tmax = 4 h, t1/2 beta = 12.3 h, U(0-60 h) = 37.5%, of the administered dose.

Adult↗
PubMed1984

Pharmacokinetics in the elderly.

The article discusses how and why drug responses are altered in elderly patients. It describes how the mutation of body composition and decay of physiological functions in the aged alters the pharmacokinetic parameters and consequently the drug responses. It also provides guidelines on which to base estimates of an accurate drug schedule.

Absorption↗
PubMed1984

SHBG pattern during the menstrual cycle.

The Authors evaluate the variation of Sex Hormone Binding Globulin during the menstrual cycle in 17 normal menstruating healthy women. The resulting data seem to show not significant modification in the protein serum level, in agreement with most of the reports in literature. A possible explanation might be the insufficient length of estrogen stimulation in the prolipherative phase. This might lead to hypothesize that in presence of marked impairments of sex steroid metabolism SHBG levels may vary significantly.

Adult↗
PubMed1983

Desire of pregnancy and desire of motherhood. Its sociocultural evolution.

Nowadays pregnancy is considered a psychosomatic experience during which personal and existential factors interact with cultural and environmental ones. This very important event causes conflictual conditions. In fact as regards to become a mother a different psychological attitude corresponds to a social-cultural change (historical environment, contraception, geographical area, etc.) that has shifted the objectives and the duties giving the woman the "theoretical" possibility to decide of her nature autonomally. This problem issues from two desires: the pregnancy and the maternity ones. Taking into account this attitude in 1200 women attending the Obstetric Psychoprophylaxis classes in 1982 at the Obstetric and Gynecological Department of Padua University, the Authors have pointed out interesting aspects concerning the way the woman today considers the conception and the pregnancy.

Attitude↗
PubMed1983

The "group" in obstetric psychoprophylaxis.

In the practice of obstetric psychoprophylaxis every method employed considered always the group both from a psychological and a pedagogic point of view. Today the group of pregnant women (or couples) is considered under various aspects: - psychological: the group as a support for members with regard to maternal and parental emotional feelings; - anthropological: the group fills up an empty vital space and becomes a "rite de passage" from a state of social identity to another one; - social: the group is a significative cultural intermediary between health services and the women-patient. The knowledge of these aspects becomes an important methodological support for group conductors. We present an analysis of our experience with groups and how this has affected the Psychoprophylaxis in the last years.

Female↗
PubMed1983

Considerations about our approach to obstetric psychoprophylaxis.

Usually the term "obstetric psychoprophylaxis" refers to a specific method or technique. We prefer to consider it as a procedure that involves on one side the woman, the child and its family, and on the other the services entitled to give pre- and post-natal assistance. In order to realize this, a reformation of our methodological parameters and a critical analysis of the results obtained are required. In the courses of obstetric psychoprophylaxis that are held in the Department of Obstetrics and Gynaecology of the University of Padua we take into consideration the following themes: - Methodological approach - Professional training of the staff - Significance of psychosocial culture in the management of the pregnancy by the health services.

Female↗
PubMed1983

Considerations on tubal sterility of presumed psychogenic origin.

The Authors evaluate a certain number of patients presenting primary or secondary infertility, in the search of any emotional problem which could be responsible for it. While it is hard to demonstrate the psychological origin in some cases of infertility and to quantify its real incidence, the Authors point out the importance of ruling out any psychological factor at the beginning of the work-up for the infertile couple and particularly while ascertaining the tubal patency through the hysterosalpingography, a diagnostic technique which can be very stressing for women.

Adult↗
PubMed1981

Premenstrual syndrome and personality traits: a study on 110 pregnant patients.

Five specific personality traits (emotivity, acceptance of sexual role, parental aptness, anxiety and depression) have been analyzed for this study of the premenstrual syndrome (PMS), conducted on a group of 110 women in advanced (8th month) pregnancy. The comparison of the results from the personality tests and from the overall assessment of the PMS (82%) establishes definite correlations between the syndrome's intensity and the tendency toward a pathologic personality. A further correlation of each personality trait and of the PMS shows that the greater deviation from normalcy affects not only those women who suffer from a severe PMS, but also those who complain of no premenstrual symptoms at all. Such a finding (as shown in the results of a separate previous study by our group) allows to conclude that a psychological normalcy or balance finds its equivalent in an absence, but more often in a scarce presence of premenstrual complaints, while an absolute absence or a very marked intensity of these complaints should correspond to the more extreme degrees of personality disturbance.

Adult↗
PubMed1981

Usefulness of cardiotocography in expulsion period.

When an expulsion-period cardiotocographic record is examined, the most important factors, to be carefully controlled, are foetal cardiac frequency, its irregularities, the presence of decelerations and, above all, the appearance of final bradycardia. The Authors have studied 196 cardiotocographic records taken in expulsion period. Apart from the above mentioned factors, they looked for correlations between pathological pictures and parity, length of expulsion period and Apgar score. Satisfactory results lead them to conclude that cardiotocography is indispensable also in expulsion period.

Bradycardia↗