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Biomedical subjects

R Chávez

Publications and source records attributed to R Chávez.

41 records · Page 3Linked to original sources
PubMedDate not supplied

[5 years' experience with parietal cell vagotomy].

The authors presents five years experience with the Parietal Cell Vagotomy in 65 cases. In this group 54 of them had duodenal ulcer, 7 cases presented duodenal ulcer and Hiatal hernia. Only 4 cases presented hiatal hernia. Clinical, radiological and gastric secretion controls show a satisfactory evolution and considerable reduction in the ion H+ concentration. The authors presented in their series 4.6% recurrence in the D.U. group, the morbidity was 1.5%, they did not report operative mortality.

Adolescent↗
PubMedDate not supplied

[Captopril protection from the nephrotoxic effects of mercury].

The experiments referred to in this article point to the fact that relatively low concentrations of Hg2+ (5-10 mM) produce damage to the internal mitochondrial membrane. This damage results in the formation of ionic channels that allow the spontaneous effusion of Ca+2 from the matrix. Together with this, the formation of channels produce the balance of the chemo-osmotic gradient, resulting in the overcoming of the transmembrane potential and the uncoupling of oxidative phosphorylation. The experiments carried out in vivo, point to the fact mercury produces acute tubular necrosis of kidney tissue. These toxic effects produced by Hg2+ in vitro with the addition of 15 microM of the inhibition of the angiotensin converting enzyme, captopril. In vivo experiments show that intraperitoneal infection of captopril (40 mg/kg) completely protects from mitochondrial dysfunction produced by mercurial intoxication.

Animals↗
PubMedDate not supplied

[Ketorolac protection in damage due to myocardial ischemia and reperfusion].

This study shows that the nonsteroidal anti-inflammatory drug. Ketorolac, has an ionophore-like action for calcium, such a drug may transfer calcium through an hydrophobic phase. This property does not affect the respiratory rate of mitochondria. These results indicate that the ionophoretic effect is not due to an uncoupling action of Ketorolac. The effect of this compound was tested in a reperfusion model where it was observed that Ketorolac (1 mg/Kg weight) administered 30 min before an ischemic period was induced, reverts the arrhythmic effect of reperfusion. These results are in agreement with the analysis of the plasmatic concentrations of the enzymes creatine kinase and lactic dehydrogenase. It was found that the levels of such enzymes were lower in Ketorolac treated group, than in the untreated one. The results clearly indicate that Ketorolac prevents from the myocardial damage induced by reperfusion, probably by avoiding calcium overload in myocytes.

Animals↗
PubMedDate not supplied

[Effect of tobacco combustion on the immunochemical properties of albumin].

During tobacco burning smoker to run up substances to contain smoke as far as pulmonary tissue that is damage. In cigarette 600 degrees C are in ignition extreme, but in the other side, in contact with edge of the mouth smoker, the temperature is lower. Smoke could be delivery tobacco products until respiratory tract when temperature gradients occur in cigarette burn. For demonstration of the immunoreactive substances in tobacco smoke condense (TSC) we used a model with two cigarette arrangements: several concentrations of bovine seric albumin (BSA) applied to experimental group of cigarettes and phosphate-saline solution (PBS), 0.15 M pH 7.5 without protein to control cigarettes. Both series, experimental and control, remained at 20 degrees C during 48 h, soon afterward TSC was obtained. Higher protein concentration was observe in the experimental TSC of cigarettes expose to more elevated quantities of BSA, this was identify with polyclonal antibodies toward BSA employing counter-immunoelectrophoresis, immunoelectrophoresis, radial immunodiffusion and hemagglutination inhibition test. In summary: TSC of treat cigarettes had a little quantity of protein (BSA), but immunochemical properties of BSA in TSC were preserve because polyclonal antibodies against BSA bind to this protein. In habitual smoker some compounds present in cigarette smoke could be induce an immune response due to immunogen in tobacco substances.

Animals↗