Biomedical subjects

R Châtel

Publications and source records attributed to R Châtel.

14 recordsLinked to original sources

PubMed1999

[Possibilities of non-hormonal drug treatment of osteoporosis].

In many countries osteoporosis is the most common metabolic bone diseases. A great deal is known about the pathophysiology and the treatment of the disease. There is a lot of treatment possibilities and many new treatments are being tested. Therapeutic agents for osteoporosis are correspondingly classified as substances primarily inhibiting bone turnover (most of them are inhibitors of bone resorption as well) and agents that appear capable of restoring bone mass previously lost (stimulators of bone formation). From a didactic point of view the distinction of these to groups is generally accepted, but pharmacologically there is a considerable overlap between two. In this review the authors evaluate non-hormonal drugs, which are being used widely in the treatment of osteoporosis. The key points of the evaluation are the mechanism of action, the effects on bone mass, bone strength and fracture.

Adult↗

PubMed1994

[Comparative study of 24-hour ambulatory blood pressure monitors with standard zero and random zero sphygmomanometers].

The aim of the study was to evaluate the accuracy of the most widespread 24-hour ambulatory blood pressure monitor in Hungary. The test was based on simultaneous measurement on the same arm with the test device and standard zero or random zero sphygmomanometer in 100 patients. The difference between the blood pressure values measured by the test device and by the standard device was calculated in each case, and a relationship between this difference and the actual blood pressure of the patient was analysed. Actual blood pressure was considered as the average of the blood pressure measured by the test and that by the standard device. Regarding the diastolic values, the mean difference between the values obtained by the test device and the standard zero sphygmomanometer was -3.8 +/- 7.55 mm Hg (p > 0.05), and that between the test device and the random zero sphygmomanometer was -0.1 +/- 6.05 mm Hg (p > 0.05). This differences did not reach statistical significance. Regarding the systolic values, the difference showed significant positive correlation with the actual blood pressure level of the patient, meaning that at higher blood pressure values the difference between the data gained by the test and standard device is greater than at lower actual blood pressure levels. Finally, according to the criteria of the British Hypertension Society, our device could be graded "C" both for diastolic and systolic values against the standard zero sphygmomanometer, and "C" for systolic and "B" for diastolic blood pressure against the random zero sphygmomanometer.

Blood Pressure Determination↗

PubMed1990

[The role of exchangeable sodium content of the body in cases of hypertension of various etiology].

Measurement of exchangeable sodium by isotope dilution is a relatively simple, reliable method for the determination of body sodium contents, which can be used in the clinical practice without significant health hazard to the patient. When computed to body surface area, the values for exchangeable sodium can be compared in patients of different body build. Exchangeable sodium may be variably increased in different clinical conditions associated with hypertension, thus increased sodium contents of the body is of major importance in the pathogenesis of hypertension caused by all forms of mineralocorticoid excess, and in the majority of patients with chronic renal insufficiency. In several endocrine disorders, e. g., acromegaly, hypothyroidism, increased sodium space does not play any significant part in the pathogenesis of hypertension. In diabetes mellitus, exchangeable sodium may be increased already prior to the development of hypertension, however it is still a matter of debate whether this abnormality is involved in the pathogenesis of hypertension in these patients. It seems now beyond any doubt that body sodium is normal in patients with essential hypertension, including those with the low renin form of the disease; nevertheless, some data indicate that blood pressure may be volume dependent in elderly patients with essential hypertension.

Diabetes Mellitus, Type 1↗

PubMed1980