Ethical and moral dilemmas.
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Biomedical subjects
Publications and source records attributed to R Chabali.
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Emergency physicians often deal with diagnostically elusive cases that may present repeatedly over the course of illness. The infant presented here had a chronic history, prompting multiple physician contacts for initially seemingly common problems. Assessing the patient's progression of symptoms over time and eliciting a brief developmental history in the emergency department (ED) helped guide decision-making toward admission and appropriate diagnostic workup.
Analyzing anion and osmolal gaps can help in the diagnosis and management of clinically elusive cases. This article presents two such cases, and reviews the clinical use of gaps.
Transient erythroblastopenia of childhood is usually a benign, self-limiting underproduction of red blood cells that often goes undetected clinically. The patient presented here, however, required crystalloid boluses and red blood cell transfusion for treatment of shock and metabolic acidosis in the emergency department. The emergency physician must be alert to the patient presenting with severe anemia and procure extra pretransfusion blood samples for anemia studies when transfusion appears imminent. The need for red blood cell transfusion in such a patient must be expeditiously recognized and, when the need exists, transfusions should be started as quickly as possible.
The superiority of either a complete blood count, erythrocyte sedimentation rate, or C-reactive protein as a generic, global screening test for bacterial infection in infants or children has not been clearly demonstrated. The few claims of superiority for one determination over another relate more to the clinical setting than marginal differences in sensitivity or specificity. Neither the complete blood count, erythrocyte sedimentation rate, or C-reactive protein has proved sensitive enough of predicting invasive bacterial infection that it can be used as an isolated measure upon which major management decisions can safely be based. Several investigators have therefore addressed whether these tests can complement each other. Unfortunately, acquisition of multiple nonspecific laboratory tests in a given clinical situation may yield widely divergent results. The C-reactive protein, complete blood count, erythrocyte sedimentation rate, and zeta sedimentation ratio are all comparably priced in the $15.00 to $30.00 range. However, if multiple tests are obtained, the cost of this approach may become unacceptably high. Current practice advocates a careful evaluation of an ill pediatric patient in an Emergency setting. The initial clinical impression of an experienced clinician based on history and physical examination frequently provides dependable information with which to direct subsequent evaluation. If bacterial infection ranks high on the differential list, relevant laboratory studies should be considered. Observation of quantitative and qualitative changes of the hematologic profile or rate of erythrocyte sedimentation are adequate tools in specific circumstances. With the resurgence of interest in the use of C-reactive protein, it too may join the ranks of convention in selected settings.
Death occurs in a small but significant percentage of patients with Kawasaki syndrome. Cardiovascular involvement is the major cause of death, which may be delayed and sudden. Much has been written about diagnosis and medical and surgical therapy. We reviewed the current understanding of this disease and its cardiovascular manifestations and offer a diagnostic and therapeutic protocol based on this review.
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