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R Chilla

Publications and source records attributed to R Chilla.

At least 37 records · Page 2Linked to original sources
PubMed1993

Cytogenetic subtyping of 220 salivary gland pleomorphic adenomas: correlation to occurrence, histological subtype, and in vitro cellular behavior.

Based on the hypothesis that three main cytogenetic subtypes of salivary gland pleomorphic adenomas can be distinguished which may also represent different etiologic entities, we investigated whether these subtypes correspond to clinical, histologic, or biologic features of 220 tumors karyotyped (including 117 tumors with detailed clinical history and histologic subtyping). The following results were obtained. As compared with the group of patients showing salivary gland pleomorphic adenomas with an apparently normal karyotype, the patients in the "8q12-group" were significantly younger (51.1 years versus 39.3 years, p < 0.001). The distribution of histologic subtypes also showed highly significant differences between the groups. Whereas the breakpoint in the 8q12 group was always mapped to a single band, no exact localization of the breakpoint in the group of tumors showing chromosome number 12 abnormalities was possible. In most cases, however, the breakpoints were clustered to 12q15. Finally, all tumors with 8q12 breakpoints showed a characteristic in vitro cellular morphology which was also observed in a few tumors with an apparently normal karyotype but in none of the tumors with the 12q13-15 breakpoint.

Adenoma, Pleomorphic↗
PubMed1993

[Infected cystadenolymphoma. A possible reason for clinical and cytologic diagnostic error "carcinoma"].

Inflamed cystadenolymphomas may mimic malignancies both clinically and cytologically. Inflammation-induced facial nerve paralysis, as a clinical sign, and atypical epithelial cells (arising from the inflamed cystic portion of the tumour), as a cytological marker of malignancy, are responsible for this false diagnosis. The diagnostic problems encountered are demonstrated by two case reports.

Adenolymphoma↗
PubMed1990

[Hypopharyngeal carcinoma and radical surgery--does such a therapeutic procedure make sense?].

From 1977 to 1983, 49 patients with carcinoma of the hypopharynx were treated, including follow-up, at the ENT clinic of the Zentralkrankenhaus St. Jürgen Strasse in Bremen. Two groups of patients with comparable tumor stage distributions were either treated with a combination of radical surgery and radiotherapy (19 patients), or not operated at all, receiving instead radiotherapy and/or chemotherapy (30 patients). The five-year survival rates (33% and 11% respectively) revealed, albeit at an altogether low level, the superiority of the radical procedure, including total extirpation of the larynx. The recommendation for radical removal of a hypopharyngeal carcinoma must therefore be made on an individual basis and with some reservation. Compromises, such as surgical management of the lymph node metastases without extirpation of the primary tumor, which is then irradiated, or the excision of the primary tumor in combination with partial resection of the larynx, ought to be made when choosing between possible therapeutic alternatives.

Carcinoma, Squamous Cell↗
PubMed1990

[Revision of the parotid--assessing the risk and indications status for re-parotidectomy].

Recurrences of benign and malignant tumors and inflammatory complications are the main indications for revision parotidectomy. Many of these operations could be avoided if the primary surgical procedure had been adequate. Revision parotidectomy is difficult to perform when the facial nerve is embedded in scar tissue. Indications for and risks of revision parotidectomy are demonstrated for typical situations such as recurrent pleomorphic adenomas and malignancies, postoperative fistulas, and recurrences of previously operated chronic parotitis.

Adenoma↗
PubMed1989

Relationship of cytogenetic subtypes of salivary gland pleomorphic adenomas with patient age and histologic type.

Sixty-nine salivary gland pleomorphic adenomas were fully karyotyped by G-banding including 40 tumors previously reported. The cytogenetic results allowed to distinguish between three major chromosomal subgroups characterized by either an apparently normal karyotype or by rearrangements of chromosome 8q12 or by rearrangements of chromosome 12q14-15. Significant correlations of these karyotypic groups with the age of the patients and histologic subgroups of the pleomorphic adenomas were found. Furthermore, our analysis revealed that the three main cytogenetic subgroups showed an uneven geographical distribution. Based on these results we have concluded that the cytogenetic groups represent different etiologic entities.

Adenoma↗
PubMed1989

[Therapy of facial paralysis in herpes zoster oticus with acyclovir].

In the present study patients suffering from facial nerve palsy caused by a herpes zoster oticus were treated with aciclovir. After therapy all patients could be controlled via clinical grading system and electromyographic observations. Aciclovir therapy did not yield any results superior to those obtained with other forms of therapy presented in the literature.

Acyclovir↗
PubMed1988

A causal relationship between chromosomal rearrangements and the genesis of salivary gland pleomorphic adenomas.

The results of chromosome analyses performed on 50 pleomorphic salivary gland adenomas in Germany are summarized herein and compared with those obtained on 100 adenomas studied in Sweden. In both series, characteristic or even specific structural chromosomal rearrangements involving either chromosome 8 or 12 were found that allowed the cytogeneticist to distinguish between subgroups. However, the significantly higher percentage of tumors with chromosome abnormalities in the adenomas examined in Germany is particularly noteworthy. In the near future, cytogenetic investigations together with molecular methods will allow investigators to describe basic mechanisms for the development of pleomorphic adenomas in terms of oncogenetics.

Adenoma, Pleomorphic↗
PubMed1988

[Metastasis of cancer of the external ear].

Follow-up of 103 patients with squamous cell carcinomas of the auricula showed that 20 of them developed regional lymph node metastases. The effect of size, site and certain histological parameters on the occurrence of metastases was assessed. The incidence of metastases correlated with increasing size of the tumour.

Aged↗
PubMed1987

[Diagnostic relevance of saliva analysis in parotid tumors].

The stimulated parotid saliva of 32 patients with unilateral parotid tumours was analyzed with respect to flow rate, protein and IgA content, amylase, kallikrein and peroxidase activities, as well as protein patterns after application of polyacrylamide gel electrophoresis. The values obtained were compared with those measured in the saliva of the contralateral healthy side. None of the parameters investigated yielded differences that could be relevant for the clinical diagnosis of parotid tumours.

Amylases↗
PubMed1987

[Bell's palsy as the initial symptom of HIV infection].

60% of all HIV-infected patients develop neurological deficits during the course of their disease. The facial paralysis of a 47 year old man which presented as a Bell's palsy is nevertheless an unusual first symptom of HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1986

[Recurrence tendency and malignant transformation of pleomorphic adenomas].

Young patients and those with the stroma-rich variant of pleomorphic adenoma have an increased risk of local recurrence. Review of 98 patients with recurrent pleomorphic adenoma showed that the primary operation is nevertheless decisive for the further progress of the disease: incomplete tumour excision and enucleation of pleomorphic adenomas were responsible for tumour recurrence which may be multiple. Recurrence in turn favours the development of carcinoma within pleomorphic adenomas. Of 23 carcinomas, 20 developed within recurrent tumours. These 20 tumours comprised 16.9% of all recurrences observed. A mean time of 16 years relapsed after the primary operation before a carcinoma developed in the recurrence. Slow and protracted tumour growth were characteristic of those carcinomas that could be also demonstrated in the original tumour (0.9% of the group of non-recurrent tumours) with a mean time of 7 years before operation. Immediate tumour removal is therefore the best prophylaxis against carcinoma. In 19 patients we showed that local recurrence due to dissemination can be avoided by appropriate measures, even after intra-operative opening of the tumour capsule.

Adenoma↗