Biomedical subjects

R Cibrián

Publications and source records attributed to R Cibrián.

5 recordsLinked to original sources

PubMed1999

Determination of the object surface function by structured light: application to the study of spinal deformities.

The projection of structured light is a technique frequently used to determine the surface shape of an object. In this paper, a new procedure is described that efficiently resolves the correspondence between the knots of the projected grid and those obtained on the object when the projection is made. The method is based on the use of three images of the projected grid. In two of them the grid is projected over a flat surface placed, respectively, before and behind the object; both images are used for calibration. In the third image the grid is projected over the object. It is not reliant on accurate determination of the camera and projector pair relative to the grid and object. Once the method is calibrated, we can obtain the surface function by just analysing the projected grid on the object. The procedure is especially suitable for the study of objects without discontinuities or large depth gradients. It can be employed for determining, in a non-invasive way, the patient's back surface function. Symmetry differences permit a quantitative diagnosis of spinal deformities such as scoliosis.

Calibration↗

PubMed1996

Value of CA 15.3 in breast cancer and comparison with CEA and TPA: a study of specificity in disease-free follow-up patients and sensitivity in patients at diagnosis of the first metastasis.

The specificity and sensitivity of a tumor marker (TM) are important in establishing its potential clinical utility for a specific type of neoplasm. CA 15.3 is a TM specific for breast cancer; it is defined by two monoclonal antibodies (DF3 and 115D8), whose specificity, in disease-free follow-up patients, and sensitivity, in patients at diagnosis of first metastasis, have been evaluated in the present study and compared with those of carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA). Serum concentrations of all three TMs were quantified in 618 individuals: 80 healthy controls, 421 patients with local breast cancer who became free of disease following locoregional treatment, and 117 patients with disseminated disease at diagnosis of metastasis. Radioimmunoassay (RIA) was the method employed, and the cut-off values obtained were 30 U/ml for CA 15.3, 5 ng/ml for CEA, and 120 U/I for TPA. The results showed CA 15.3 and CEA specificities to be analogous (95.7 and 95.5%, respectively). TPA specificity (81.9%) was lower (p < 0.001). During adjuvant therapy, CA 15.3 serum levels were seen to increase, followed by a normalization of concentration after terminating therapy. On the other hand, CA 15.3 and TPA sensitivities (64.1 and 67.5%, respectively) were greater than for CEA (44.4%, p < 0.01). It is concluded that CA 15.3 is a useful TM for breast cancer, as it offers a greater sensitivity than CEA and a higher specificity than TPA. Combining CA 15.3 and CEA fails to increase CA 15.3 sensitivity, while combining CA 15.3 with TPA increases false-positives and so likewise offers no additional benefit.

Adult↗

PubMed1988

Speckle correlation technique to determine roughness in the dermatologic interval.

A non-invasive method is proposed to determine human skin roughness. The technique is based on measurement of the correlation between two field distributions scattered by a metallised triafol (cellulose acetate foil) replica of the epidermal area to be analysed. The two speckle patterns are produced from the same rough surface illuminated by two coherent plane waves (He-Ne laser) under two slightly different angles. The accuracy of the method is highlighted by measurements made on a set of standard samples with roughnesses previously determined by mechanical profilometry. Analysis of the results indicates a precision of around 10%, and an applicability within the interest range of very rough surfaces in excess of 4-5 microns.

Humans↗

PubMedDate not supplied

CA 15.3, CEA and TPA tumor markers in the early diagnosis of breast cancer relapse.

To evaluate the utility of CA 15.3 in detecting breast cancer relapse before clinical evidence of metastatic disease, serial determinations of CA 15.3 serum levels were made in 444 disease-free patients after surgery, during 36 months of follow-up. The results were compared with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA). The study found CA 15.3 to be more sensitive as an early indicator of relapse than CEA or TPA; moreover, simultaneous determination of the other markers offers no information additional to that obtained by CA 15.3 alone.

Adult↗

PubMedDate not supplied

Eruption cysts: retrospective clinical study of 36 cases.

The eruption cyst is a lesion associated with an erupting tooth. It appears as a transparent, bluish, blue or blue-black swelling of the alveolar mucosa, over a temporal or permanent tooth in eruption. The analysis of the thirty-six eruption cysts cases studied, corresponding to twenty-seven patients, revealed that their most frequent location is in the maxillary permanent dentition, and that they mostly occur in a single presentation, and in an age-range of between five and nine years. Six cases out of the twenty-seven patients studied showed the characteristic of presenting two or more eruption cysts, and in three of these cases, the lesions were bilateral, symmetrical and simultaneous. Two other patients had been previously diagnosed with cyst diseases. This would suggest that, in addition to the possible infection-trauma origin, there is in some cases the possibility of a predisponent tendency.

Age Distribution↗