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Biomedical subjects

R Colin

Publications and source records attributed to R Colin.

At least 145 records · Page 8Linked to original sources
PubMed1980

Calcitonin-producing pancreatic somatostatinoma.

A pancreatic somatostatinoma metastatized to the liver was detected in a 70-yr-old woman presenting with chronic diarrhea, steatorrhea, pancreatic insufficiency, diabetes mellitus, and achlorhydria. At immunocytochemistry, most tumor cells stored both somatostatin and calcitoninlike substances. Chromatography of acid extracts of the tumor on G50 Sephadex gave two distinct peaks coeluting with cyclic ovine somatostatin and human calcitonin, respectively, thus ruling out the hypothesis of a single cross-reacting molecule synthetized by the neoplastic cells. When the tumor was extracted at neutral pH, larger molecular forms of the above components were found, which accounted for less than 20% of the total immunoreactivity. Gel permeation of plasma showed that the circulating calcitonin- and somatostatinlike components consisted of three and four different forms, respectively, including components of molecular weights similar to those of the reference peptides. Inhibition curves and immunoadsorption experiments indicated that the large forms were immunologically similar, if not identical, to the corresponding standard preparations. The present case illustrates the occasional ability of neoplastic somatostatin cells of pancreas to synthetize simultaneously components immunologically related to somatostatin and calcitonin. These two inappropriate secretions could account for the symptoms displayed by this patient.

Adenoma, Islet Cell↗
PubMed1980

[Effect of protein and energy intake on nitrogen metabolism of undernourished patients on continuous enteral nutrition].

Nitrogen balance, energy balance and respiratory quotient were measured in 18 undernourished patients fed with continuous enteral nutrition in order to assess the effects of: a) various levels of protein and energy intakes with a fixed diet composition; b) energy/nitrogen ratio; c) proportions of carbohydrates in energy intake. The results were the following: 1) With energy intakes from 4,880 to 8,360 kJ/m2/day (protein: 18 p. 100) nitrogen balance and net protein absorption were significantly correlated with nitrogen intake (respectively P less than 0.01 and P less than 0.001). 2) Nitrogen balance was not significantly different whether the patient received normo (energy/nitrogen = 476 kJ/g) or hypernutrition ( energy /nitrogen = 1,056 kJ/g). 3) Nitrogen balance was not different in 6 patients receiving the same energy and nitrogen intakes but 80 or 55 p. 100 carbohydrates; high carbohydrates diet induced lipid synthesis. These results confirm the value of continuous enteral nutrition to positive nitrogen balance in undernourished patients. Except when energy expenditure level is very high they do not support a policy of routinely use hypernutrition with high carbohydrates diet.

Adult↗
PubMed1979

[Gastrointestinal haemorrhage related to alcoholic cirrhosis. Prognostical influence of digestive lavage (author's transl)].

During gastrointestinal bleeding associated with cirrhosis, the presence of blood within the lumen of the gut may cause or favorise the onset of hepatic coma. Digestive lavage by rapid intragastric infusion of an isotonic solution based upon mannitol may reduce the mortality due to hepatic coma. The value of this method was studied retrospectively by comparison of two series of haemorrhagic complications: Group I-1971-1976: 224 haemorrhagic complications treated in the usual manner; Group II-1976-1977: 127 haemorrhagic complications treated in accordance with a protocol which included digestive lavage. The results indicate the prognostic significance of certain clinical signs (ascites, jaundice, shock), and also made it possible to determine the cause of death and to demonstrate a reduction in mortality in the group treated by digestive lavage (p < 0.02), concerning only deaths as a result of hepatic coma (p < 0.01) above all in forms with a poor initial prognosis with shock or decompensation with jaundice and ascites.

Adult↗
PubMed1979

Oral BCG vaccine in Crohn's disease.

In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn's disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking the control preparation (P greater than 0.1). No significant benefit from oral BCG treatment has been demonstrated.

Adolescent↗
PubMed1979

Elastic properties of the rectal wall in normal adults and in the patients with ulcerative colitis.

The elastic properties of the rectal wall have been studied in 16 normal adults (group I) and in 24 patients with ulcerative colitis, during a nonactive (13 cases, group II) or an active period (11 cases, group III). The rectal intraluminal pressures after accommodation to the distension were significantly higher in group III than in groups I and II. These pressures were not related to distending volumes in groups I and II but were correlated with the distending volumes in group III. The rectal elasticity coefficient was significantly greater in group III than in the other two groups. There was an inverse correlation between the rectal elasticity coefficient and the rectal area. These results suggest a loss of the rectal distensibility in active colitis.

Adolescent↗