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Biomedical subjects

R Collier

Publications and source records attributed to R Collier.

14 recordsLinked to original sources

The job-finding module: training skills for seeking competitive community employment.

The opportunity to return to work is often the culmination of extensive and collaborative efforts by clients, psychiatrists, and allied mental health and rehabilitation practitioners. Successful vocational placement and tenure is a victory not only for each individual client but also for the comprehensive set of services and supports established to foster this self-determination. Much as a chain is only as strong as its links, successful job placement must be viewed as but one link in a comprehensive rehabilitation program. Our research in competitive community employment placement over the past decade has resulted in the development of the Job Finding Module, as our contribution to one link of this evolving chain of necessary treatment and rehabilitation services for the seriously mentally ill.

Aspirations, Psychological

Correlations between psychiatric disabilities and vocational outcome.

Eighty-nine subjects were recruited from inpatient and community psychiatric treatment programs in the Los Angeles area to participate in the Brentwood Job Finding Club. They were trained in job-seeking skills and were given logistical support during their job search. Thirty-six percent either obtained a job or entered a job training program. Persons with good work histories, good job interviewing skills, and nonpsychotic diagnoses were more likely to find employment. Persons with psychotic diagnoses and poor work histories and those receiving Supplemental Security Income were the least successful.

Activities of Daily Living

A trial of the calcium antagonist felodipine in hypertensive type 2 diabetic patients.

Although calcium antagonists may impair insulin release in vitro, clinical studies have produced conflicting results. Felodipine is a highly selective dihydropyridine calcium antagonist effective in the treatment of hypertension. The efficacy of felodipine was assessed in a double-blind randomized placebo cross-over study of 21 Type 2 diabetic patients with primary hypertension, 13 men and 8 women, with an age of 61 (range 46-73) years. Thirteen were controlled on oral hypoglycaemic therapy and 8 on diet alone. Mean (SD) blood pressure (mmHg) was 176(20)/102(8) after a 2-4 week placebo run-in period, 169(21)/101(8) during the subsequent placebo period compared with 151(15)/88(9) after 4 weeks felodipine therapy (p less than 0.001). Nineteen patients required 5 mg twice daily and 2 patients 10 mg twice daily to achieve a target diastolic pressure of 95 mmHg. Side-effects seen with felodipine included ankle oedema, facial flushing, headache, and dizziness. During oral glucose tolerance tests performed after the felodipine and placebo phases, mean (SD) fasting blood glucose was 9.5(3.1) and 9.0(3.0) mmol l-1, respectively (NS), and the 90 min (peak) blood glucose was 19.1(4.8) and 18.1(4.8) mmol l-1, respectively (NS). Glycosylated haemoglobin and fructosamine concentrations likewise showed no significant changes.

Apolipoproteins

Discitis after discography.

A series of nine patients with post-discography discitis were evaluated to help delineate the clinical course. The most consistent sign was the marked exacerbation of neck or back pain. This then was followed by an elevated sedimentation rate at an average of 20 days, followed by a positive bone scan at an average of 33 days. Of note is that seven patients initially had negative bone scans at an average of 18 days. Five out of nine patients had changes on plain roentgenograms between 14 and 51 days after discography. Magnetic resonance imaging was performed in six patients; two of these patients were scanned twice. Three scans were negative and five were positive (2 patients initially had negative scans that later became positive). The course of lumbar discitis ranged from 8 to 11 weeks, and cervical discitis from 6 to 7 weeks, with the latter usually resulting in spontaneous fusion.

Adult

Acoustic simulation experiments with preprocessed speech for an 8-channel cochlear implant.

A speech processor for simulation of preprocessed speech in cochlear implantation has been developed. An acoustic simulation of spectrally reduced speech was presented to 169 normally hearing subjects. Several perceptual tests with 9 different filter conditions were carried out. The intelligibility of sentences and the discrimination of phonemes in nonsense syllables were measured. It was established that even within one test session, an important learning effect occurred.

Cochlear Implants

Consequences of spatial sampling by a human photoreceptor mosaic.

The short wavelength color mechanism in the human visual system can distinguish gratings from uniform fields of the same average radiance at spatial frequencies that are twice as high as the highest at which it can resolve bars in the grating. This discrimination above the resolution limit is associated with a splotchy or mottled appearance of the grating similar to two-dimensional noise. The most plausible explanation for the mottled pattern is that it is a moiré pattern produced by aliasing (spatial undersampling) by an irregular and sparse mosaic of short wavelength cones.

Color Perception

Declination: construct or intrinsic feature of speech pitch?

Declination is taken as the focus of studying pitch phenomena from an acoustic, physiological and perceptual point of view. It is shown that originally declination was no more than a theoretical construct to account for the interpretation of acoustic F0 recordings. Recently, psycholinguistic considerations have enhanced the domain of application so as to account for this phenomenon. The literature is reviewed and the authors take issue over the various claims put forward by others, such as the dominance of the topline over the baseline approach, and the amount of pre-programming involved in declination, as manifested in its slope and in linguistically determined resetting.

Humans