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Biomedical subjects

R Cook

Publications and source records attributed to R Cook.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

The dosimetric properties of an intraoperative radiation therapy applicator system for a Mevatron-80.

An applicator system for intraoperative radiation therapy has been fabricated which does not require physical docking with the accelerator. A dosimetric study has been completed which documents the properties of this system for a variety of electron beam energies, applicator sizes, collimator settings, both primary and secondary, and source-surface distance (SSD) settings. Sensitivity of the system to common misalignment errors was also determined. Results indicate (a) applicator leakage of less than 5%, (b) beam flatness to within plus or minus 5% at the dMAX with a single primary collimator setting, (c) smooth changes in output with cone size, beam energy and SSD, and (d) negligible changes in dose distributions within alignment errors permitted by the system.

Brachytherapy↗
PubMedDate not supplied

Effects of a high-starch diet with low or high fiber content on postabsorptive glucose utilization and glucose production in normal subjects.

The effects of fiber, added to a high-starch diet, on glucose and insulin metabolism were studied in seven healthy men in a controlled environment. Diets rich in starch (carbohydrate provided 62% energy) contained either 16 g or 100 g of fiber from several sources of food and were given for 10-day periods. Two parameters of glucose control were measured: glucose metabolism during insulin-glucose infusions (seven subjects) and glucose production measured by infusing tritiated glucose tracer (five subjects). Three sets of studies were carried out in the sequence: low-fiber, high-fiber, low-fiber. The respective mean values (+/- SE) for glucose utilization were 6.70 +/- 1.4, 7.01 +/- 1.02, and 6.77 +/- 1.34 mg/kg X min. Analysis of variance failed to show a significant effect of dietary change. Values for basal glucose production were 2.0 +/- 0.1, 1.9 +/- 0.2, and 2.4 +/- 0.3 mg/kg X min with the low-fiber, high-fiber, and low-fiber diets, respectively, which were not significantly different. The one significant response to the high-fiber diet was a lowering in plasma cholesterol, the mean values for the seven subjects during the three periods being 154 +/- 12, 138 +/- 10, and 156 +/- 13 mg/dl (P less than 0.05).

Adult↗