[Lyon hemoglobin: discovery of an abnormal hemoglobin due to deletion of aminoacids (beta 17-18 (A 14-15) lys-val equals 0)].
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Biomedical subjects
Publications and source records attributed to R Creyssel.
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The study of the effect of triamterene on the movements of sodium and potassium shows: the absence of influence of triamterene on sodium movements, and the decrease of the entry of potassium in red blood cells when the solution contains triamterene. This effect of triamterene might be one of those explaining the potassium-sparing effect of this product.
In 1000 patients with monoclonal gammapathies, heavy and light chains typing of the monoclonal Ig was performed. Class distribution of the heavy chains showed the following percentages : IgG = 56.60%; IgA = 17.0%; IgM = 14.5%; IgD = 0.3%; Light chain gammapathies (including Bence-Jones proteinuria without serum M-component) = 11.6%. The chi/lambda ratio was 663/337. Such results agree with figures from most statistical studies. Beside the well-known linkage between IgM and chi types in pathological macroglobulinemia, the quite high incidence of lambda chain type of light chain components is to be noticed. The frequency of gamma G type of M-component is significantly higher in patients demonstrating no symptoms of myeloma or lymphoma. chi/lambda ratio seems to be slightly affected by aetiological features.
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