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Biomedical subjects

R Cristodorescu

Publications and source records attributed to R Cristodorescu.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Indication of cardiac surgery in infective endocarditis.

From the 33 patients with infective endocarditis (IE) hospitalized in the 1st Clinic of Internal Diseases, Timişoara between 1981 and 1984, in 5 (4 men and one woman) ranging in age from 21 to 52 years (mean 38) cardiac surgery was indicated and aortic (3) and mitral (2) valve replacements were performed. Valve replacement was performed for: 1) rapid/slow progressive hemodynamic deterioration with intractable congestive heart failure associated with ruptured chordae on posterior leaflet of mitral value (1 case); perforated aortic cusp (1 case); 2) prosthesis endocarditis (1 case); 3) precocious recurrence of IE (1 case); 4) uncontrollable infections (1 case). Echocardiography was helpful in all the cases by permitting recognition and evaluation of the preexistent lesions, and by the supplying of characteristic vegetations (all echocardiographic findings were confirmed by open heart surgery). Likewise it proved an accurate method in assessing pre- and post-operative left ventricular performance. In conclusion it is considered that early valve surgery in IE is indicated in hemodynamic deterioration, prosthetic endocarditis or impossibility to control septicemia. Echocardiography is the most useful noninvasive method for the pre- and postoperative evaluation of the patients investigated.

Adult↗
PubMedDate not supplied

M-mode echocardiography in hypertensive heart disease.

Left ventricular hypertrophy (LVH) is both a target organ response to hypertensive vascular disease and a factor that might be responsible for other cardiovascular events. Therefore we studied by means of echocardiography 41 patients with untreated hypertension classified into 4 groups according to electrocardiographic and chest X-ray LVH criteria. The patients in group IV had in addition a history of coronary disease. Thirty-seven patients (92%) presented concentric LVH and 4 patients combined LVH and dilatation. Five patients from group IV presented impairment of interventricular septum or posterior wall motion. Thirty-seven patients (92%) had increased left ventricular mass (p less than 0.01). Ejection fraction was normal in groups I, II and III but significantly decreased (p less than 0.001) in group IV. We conclude that LVH is part of the natural evolution of hypertensive vascular disease. Echocardiography proved to be the most indicated method for the assessment of cardiac dimensions and function in hypertensive heart disease.

Adult↗
PubMedDate not supplied

Echocardiographic approach to the early diagnosis of congestive cardiomyopathies.

M-mode echocardiography was used to study left ventricular (LV) function in 25 patients with congestive cardiomyopathy (CC). Good discrimination of patients with CC from a control group of normal subjects was possible using echocardiographic parameters. Symptomatic patients (group II) with CC had a significantly larger LV end-diastolic diameter (LVED) than the asymptomatic ones (group 1) but the differences in the shortening fraction (SF), ejection fraction (EF), and mean velocity of circumferential fiber shortening (Vcf) were not statistically significant. Asymptomatic patients showed significant differences from normal in LVED, SF, EF and Vcf. End-systolic wall stress is a quantitative index of true myocardial afterload that can be plotted against LV end-systolic diameter to give an index of contractility independent of loading conditions. End-systolic wall stress in normal subjects (64.80 +/- 19.50 X 10(3) dyn/cm2) was significantly lower than in patients with CC (169.6 +/- 13.43 X 10(3) dyn/cm2). In conclusion the LV echocardiographic parameters can be conveniently combined to provide a good recognition and estimation of patients with CC, even in early stages.

Adult↗
PubMedDate not supplied

Echocardiographic evaluation of left ventricular function before and after cardioversion of atrial fibrillation to normal sinus rhythm.

Echocardiographic measurements were obtained in 20 patients before cardioversion immediately after and two, four and six hours after cardioversion to normal sinus rhythm. At six hours after cardioversion there was no significant change in heart rate, left atrial diameters (LAD), left ventricular end-diastolic diameters (LVEDD) or left ventricular end-systolic diameters (LVESD). On follow-up one month to nine months after cardioversion, 14 of the 20 patients (70%) remained in normal sinus rhythm. Neither LAD, LVEDD, or LVESD, nor the presence or amplitude of the A-wave on the mitral valve echogram correlated with the persistence or normal sinus rhythm.

Adult↗
PubMedDate not supplied

Renin-sodium profile and its therapeutical implications in arterial hypertension.

In 35 patients with moderate or severe essential hypertension (EH) four groups could be identified by plasma angiotensin II (AII) (formula: see text) and by exchangeable sodium (ENa) (formula: see text) determination. In 6 patients with high AII (135.9 pg/ml +/- 26.29) and normal ENa (98.83% +/- 1.40) propranolol significantly lowered both blood pressure (BP) and AII, suggesting that these forms of EH are renin dependent. In 15 patients with normal AII (36.43 pg/ml +/- 2.27) and high ENa (124.23 +/- 2.78) and in 6 patients with low AII (8.36 pg/ml +/- 3.39) and high ENa (125.16% +/- 5.71) the maximal hypotensive effect was achieved after ENa reduction with thiabutazid. These forms of EH appear to be volume-sodium dependent. In 8 patients with increase of both AII (76.53 pg/ml +/- 5.72) and ENa (112% +/- 1.72), propranolol associated with thiabutazid lowered the BP, AII and ENa suggesting that these cases are mixed forms. ENa determination appears to be a reliable index for renin profiling; such a renin-sodium profile allows to identify some pathophysiologic forms of arterial hypertension.

Adult↗
PubMedDate not supplied

Exercise testing for assessing the effectiveness of digitalis therapy in compensated heart diseases.

Exercise pulse rate (EPR) during a 6-minute exercise testing and recovery pulse rate (RPR) 5 minutes following the test were determined in three groups of subjects before and after rapid digitalization. Ten normal subjects showed no significant changes in heart rate after rapid digitalization. EPR and RPR decreased and FPR/RPR ratio increased significantly after administration of the cardiac glycoside in 7 patients with congestive heart failure. A similar response was found in 25 out of 36 patients with compensated heart disease (69.4%). Such a response suggests a beneficial effect of chronic digitalis therapy in cardiac patients without heart failure.

Adult↗