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R D Anbar

Publications and source records attributed to R D Anbar.

12 recordsLinked to original sources
PubMed1990

Does lithium carbonate affect the ion transport abnormality in cystic fibrosis?

Lithium is known to affect several aspects of cellular regulation which may be related to ion channel function in epithelial cells. To determine whether the ion transport abnormality in cystic fibrosis (CF) is affected by lithium with resultant changes in clinical status, 36 CF patients, 12-37 years old, were enrolled in a 14 week, double-blind, placebo-controlled trial. Eighteen patients were randomly assigned to receive lithium carbonate for 10 weeks. At the end of therapy their average serum lithium concentration was 0.56 +/- 0.06 mmol (SEM) per liter. Their sweat chloride concentration fell from 92.1 +/- 4.8 mmol per liter to 87.4 +/- 4.0 mmol per liter after 10 weeks of therapy (P = 0.07) and rose to 94.4 +/- 3.5 mmol per liter 4 weeks after end of therapy (P less than 0.001 compared to results at end of therapy). Their forced vital capacity (FVC) fell from 72 +/- 5.3% of predicted to 66 +/- 5.1% of predicted after 4 weeks of therapy (P less than 0.01), and their forced expiratory volume in one second (FEV1) fell from 56 +/- 5.5% of predicted to 51 +/- 5.5% of predicted after 4 weeks of therapy (P less than 0.01). In a non-blind assessment, performed 19 weeks after the end of therapy, their FVC and FEV1 had risen and were not significantly different from baseline. Sweat chloride, FVC, and FEV1 remained unchanged in the placebo group throughout the period of study.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Hypomagnesemia: a multifactorial complication of treatment of patients with severe burn trauma.

Hypomagnesemia is reportedly a common complication of care during the early period of recovery from major trauma. Aminoglycoside treatment, by provoking inappropriate renal magnesium wasting, may contribute to the frequency of hypomagnesemia. We examined the magnesium (Mg) status of six severely burned adolescents during the early phase of recovery. Although provision of Mg met recommended levels, hypomagnesemia occurred in every patient. Two of five of our patients were hypomagnesemic during gentamycin treatment, and five of five during subsequent tobramycin therapy (including the three not affected by gentamycin). Additional episodes occurred in five patients in the absence of aminoglycosides. An interrelationship between Mg status and efficacy of potassium repletion is detailed for one patient. Hypomagnesemia during tobramycin treatment was associated with refractoriness to potassium repletion. Recurrence of hypokalemia during a subsequent diuresis-induced hypomagnesemia was prevented by Mg supplementation. The Mg requirement is increased during recovery from severe burns and appears to exceed that provided by commercially available enteral formulations.

Adolescent↗