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Biomedical subjects

R D Culpepper

Publications and source records attributed to R D Culpepper.

8 recordsLinked to original sources
PubMed1988

Operative management of ipsilateral fractures of the hip and femur.

Thirteen patients with ipsilateral hip and femoral shaft fractures are discussed. In nine patients, the femoral shaft fracture was managed by a combination of dynamic compression plating with a medial cancellous bone graft and either multiple cancellous screws or a dynamic hip screw for the proximal fracture (Group I). Four patients had Ender pin fixation (Group II). In Group I, both fractures were united within 16 weeks in all patients, and at least 90% of normal hip and knee motion was regained. Nonunions developed in two of the four Group II patients. Immediate separate fixation of ipsilateral hip and femoral shaft fractures allows definitive management of the proximal fracture and immediate mobilization without external support and provides satisfactory results with a low complication rate.

Adult↗
PubMed1976

Hemorrhagic shock in dogs. Comparison of treatment with shed blood alone versus shed blood plus Ringer's lactate: intravascular pressures, cardiac output, oxygen consumption, arteriovenous oxygen differences, extracellular fluid PO2, electrolyte changes, and survival rates.

The purpose of our study of hemorrhagic shock in dogs was to examine the efficacy of adding Ringer's lactate to shed blood replacement in increasing animal rates. The standard Wiggers' hemorrhagic shock technic was used in two groups of ten animals each. Intravascular pressures, cardiac outut, oxygen consumption, arteriovenous oxygen differences, extracellular fluid PO2 and pH, electrolyte changes, and survival rates were determined. There was a positive correlation between changes in cardiac output, central venous oxygen content, and PO2 and extracellular fluid PO2 as measured using subcutaneously implanted Silastic tubing and perforated plastic balls. Four of the dogs that received shed blood alone survived, whereas five of the dogs that received shed blood plus Ringer's lactate survived. This difference was not statistically significant.

Animals↗
PubMed1976

Birth sequence in mice.

Succession of deliveries at parturition was determined in mice following a marker injection in utero. The data failed to refute the hypothesis of a random birth order, as delivery from either uterine horn was found to be unpredictable. In addition, significantly more females delivered the first pup from the right uterine horn, supporting the concept of a "physiological dominance" for the right side of the mouse reproductive tract.

Animals↗
PubMed1975

A blood pressure-regulating device for inducing hemorrhagic shock.

An instrument for producing closely controlled and repeatable hemorrhagic shock in laboratory animals is described. A Sarns roller pump, controlled by an electronic device, is used to pump blood in and out of the animal at a constant rate. Photoelectric cells are used to sense pressure changes and depending on their configuration, the pump runs forward or backward or stops. Pressures are accurately maintained, bleeding and reinfusion rates are controlled, and a record of bleeding patterns is provided.

Animals↗
PubMed1975

Successful orthotopic allotransplantation of hearts from dogs in irreversible shock.

The viability of the heart from irreversibly shocked dogs was evaluated. Thirty-one mongrel dogs were used to develop a uniformly lethal hemorrhagic shock model. The final model utilized a 30 mm. Hg mean arterial pressure with a 40 percent decompensation (uptake of reservoir blood). All control dogs subjected to this procedure died within 24 hours. Eleven hearts were transplanted following the shock procedure. Blood samples were drawn at intervals and analyzed for Po2, pH, glucose, oxygen content, and hematocrit. Cardiac outputs and ECG's were taken before and after transplant. All parameters measured returned to control levels following the transplants. Of the dogs receiving heart transplants, 10 survived more than 24 hours and eight survived more than 7 days. Compared with the survival of the shock model experiments, the survival of the transplant recipients was significant at the p less than 0.01 level. These results suggest that deterioration of the heart is not the factor which prevents recovery from irreversible hemorrhagic shock.

Animals↗
PubMed1975

Heart transplantation in endotoxin shock.

The condition of the heart from dogs in endotoxin shock was evaluated, and all dogs in the control group receiving 5 milligrams per kilogram to Eschericia coli endotoxin died within two to 14 hours. Hearts from four other dogs receiving the same dosage of endotoxin were allografted orthotopically into healthy recipient dogs. The donor heart was taken in the terminal phase of shock, after the blood pressure of the donor had declined to 50 millimeters of mercury or less. All four heart allografts functioned normally in the healthy hosts, demonstrating that lethal levels of gram-negative endotoxin do not produce direct irreversible damage to the myocardium or to the conduction mechanism of the heart. This also was shown in one pair of monkeys; the donor monkey had received ten times the dosage of endotoxin used in the dogs. This heart transplant model offers considerable advantage in functional studies of the heart after irreversible shock.

Animals↗