Biomedical subjects
Publications and source records attributed to R D Danese.
Quantitative ultrasound (QUS) is receiving considerable attention in the assessment of osteoporosis because of its ease of use, lack of radiation exposure, region of interest, and relatively low costs. These features have made the technique appealing for screening adult and pediatric patients. This article discusses some of the clinical applications, limitations, and strengths of QUS.
Glucocorticoid use is associated with the risk of hyperglycemia in patients without known diabetes mellitus and worsened glycemic control in diabetic patients. The effects are greater in the fed than fasting state. Management includes use of diet and exercise (as appropriate for the individual) in all patients. Mild hyperglycemia can often be managed with oral agents, especially those with rapid onset of action. Marked hyperglycemia, especially in diabetic patients or patients with liver or renal disease, requires insulin. Adjustments in insulin can be done both in anticipation of the glucocorticoid effect and based on home glucose monitoring. The effects of glucocorticoids on hyperglycemia usually remit within 48 hours of discontinuation of oral administration.
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Cushing's syndrome refers to the signs and symptoms that result from excessive glucocorticoid action, usually from endogenous production or exogenous administration. This article reviews the pathophysiology of hypertension in Cushing's syndrome and current concepts in the diagnosis and treatment of this disorder.