Biomedical subjects

R D Dustin

Publications and source records attributed to R D Dustin.

3 recordsLinked to original sources

PubMed1977

Monocyte-macrophage function in the newborn.

Analysis of 20 human cord blood samples for monocyte-macrophage function demonstrates a selective defect in monocyte cellular chemotaxis. Monocyte bacterial phagocytosis, phagocytosis of paraffin oil particles, and bacterial killing of staphylococcus 502A were normal when compared with 30 healthy young adult controls. Impaired response of neonatal monocytes to chemotactants is an additional host defense defect that may help explain the undue susceptibility of neonates to certain infectious agents.

Adult↗

PubMed1977

Defective monocyte chemotaxis in mycosis fungoides.

Monocyte-macrophage function was studied in 14 patients with histologically confirmed mycosis fungoides. Three component parts of the monocyte-macrophage system were examined. Monocyte bacterial phagocytosis and bacterial killing were normal. However, a defect in directional mobility (chemotaxis) was found in patients with mycosis fungiodes (P less than .0025) when compared to 35 healthy controls. Defective chemotaxis was present regardless of disease stage or therapy. This defect in monocyte chemotaxis represents a previously unrecognized immune deficiency and may help explain the frequent infections found in patients with mycosis fungoides.

Adult↗

PubMed1975

Quantitative assays of human monocyte-macrophage function.

Monocyte-macrophages are required for the development of cell mediated immunity to a variety of microorganisms and tumors. Quantitative assays of human monocyte-macrophage function would be most useful in the evaluation of cell mediated immune function in man. Five quantitative assays are described that provide a human monocyte-macrophage function profile. These assays parallel the physiologic steps necessary for monocyte-macrophages to function as phagocytes: 1) chemotaxis, 2) opsonization, 3) phagocytosis, 4) phagocytosis-induced metabolic stimulation and 5) destruction of foreign material. Application of these quantitative assays will allow detection and dissection of disorders of monocyte-macrophage function in man.

Adult↗