Biomedical subjects

R D Fantozzi

Publications and source records attributed to R D Fantozzi.

3 recordsLinked to original sources

PubMed1991

Development of monoclonal antibodies with specificity to oral squamous cell carcinoma.

A panel of five monoclonal antibodies have been produced that show binding when directed against human oral head and neck squamous cell carcinomas. These monoclonal antibodies are derived from antibody-secreting cells obtained using cell hybridization techniques. The activity of the antibody was tested in vitro against oral head and neck squamous cell carcinoma (n = 10). Control groups included normal oral mucosa (n = 7), hyperkeratosis (n = 5), mild dysplasia (n = 4), and severe dysplasia (n = 3). Results using immunoperoxidase staining confirmed the binding of the five monoclonal antibodies to human head and neck squamous cell carcinoma cells, with predominant reactivity (50% to 90%) in the majority of the specimens, compared with negative (0%) to weak (less than 5%) or focal (5% to less than 50%) reactivity in the control specimens.

Animals↗

PubMed1985

Extraglandular Warthin's tumors.

Warthin's tumor or papillary cystadenoma lymphomatosum (PCL) represents a clinically significant entity, not because of pernicious behavior, but because its cytohistological characteristics tell us much about the development and morphology of the parotid region. Three cases operated on in which PCL developed in an extraglandular location from the parotid, formed the basis for a series of observations on what is known about: 1. etiology of PCL; 2. the nature of the lymphocytic components; 3. the relatively high incidence of bilateral and multiple occurrence, as well as male predominance. These studies employed immunohistological techniques using a series of monoclonal antibodies.

Adenolymphoma↗

PubMedDate not supplied

Heterotopic brain in the middle ear: CT findings.

A soft tissue mass was found by CT in the mesotympanum of the left middle ear of a 4-year-old boy. This lesion was without radiologic or surgical evidence of associated bony defect or communication with the intracranial cavity. Pathological examination revealed heterotopic brain tissue. Although heterotopic brain tissue in the middle ear is rare, it should be considered in the differential diagnosis of soft tissue middle ear masses.

Brain↗