Biomedical subjects
Publications and source records attributed to R D Ganatra.
The effects of triiodothyronine and thyroxine on metabolism and growth of bacteria were studied. It was observed that over a certain range of concentration thyroxine and triiodothyronine produced increase in 14CO2 release from [14C]-labeled glucose and also stimulated bacteria growth.
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99MTc-pyridoxylidene glutamate is a good agent to visualize the hepatobiliary system. The method of preparation and quality control, and preliminary data on its behaviour in human controls is presented. In humans the gall bladder could be well seen in about 15--20 minutes after intravenous injection.
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A study of some parameters affecting the time activity histogram of an intravenous bolus injection of radioactivity was performed. A scoring system for bolus compactness was attempted. A score of 2 and above was considered to be a satisfactory bolus. Volumes less than 1 ml tended to result in a satisfactory bolus. The nature of the radiopharmaceutical injected, different injecters and age of the patient did not affect the score. Thyrotoxic patients gave the best bolus score.
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The stability of tin-phytate solution stored at room temperature has been studied. It was found that there is a pronounced increase in the rate of degradation of this complex, both temperature and phase change contributing to the enhanced rate of decomposition. The kidney uptake which is occasionally observed clinically with an aged tin-phytate complex labelled with 99mTc is probably due to an intermediate product which subsequently breaks down on further storage. Lyophilized tin-phytate complex 'kits' have a longer shelf life than the aqueous complex.
This paper outlines the method of preparation of 99m-Tc-phytate and its use for scanning the reticuloendothelial system. The tissue distribution studies in mice and rats indicate that 99m-Tc-phytate is a safe and effective liver imaging agent. This was confirmed by preliminary studies in human subjects. The stability of the aqueous tin-phytate complex is remarkably good, and it could be successfully used for more than two months to prepare the labelled product.
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Radioiodine uptake in liver metastases was observed in two patients with follicular carcinoma of the thyroid.
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