PubMed Health⌕ Search

Biomedical subjects

R D Griffiths

Publications and source records attributed to R D Griffiths.

At least 73 records · Page 4Linked to original sources
PubMed1988

The effect of mazindol on growth hormone secretion in boys with Duchenne muscular dystrophy.

Mazindol has been reported to improve muscle function in Duchenne muscular dystrophy (DMD) by virtue of its growth hormone (GH) suppression. The effects were studied on GH secretion (in response to growth hormone releasing factor and sleep) of mazindol 2 mg daily for 3 months in five boys with DMD. No consistent change was found following mazindol therapy. Adverse effects were noted in all the boys which may preclude long term use of mazindol in DMD.

Child↗
PubMed1987

Magnetic resonance spectroscopy in the recognition of metabolic disease.

Magnetic resonance (MR) is rapidly entering many fields of clinical medicine following a long history as a powerful tool in physics and chemistry. The non-invasive and non-destructive property of this technique has enabled the chemical shift in higher magnetic fields to be exploited to identify and quantitate metabolites in both in vitro and in vivo analysis. High resolution proton spectroscopy of body fluids has been shown to be complementary with established analytical techniques, while the development of whole body large bore magnets is enabling both the study of structure and metabolism in humans in vivo. Phosphorus MR spectroscopy has provided a method of monitoring ATP production and utilisation in situ in both perfused preparation and intact tissue. In human muscle it has been possible to test established theories of tissue energy metabolism. It provides a unique method with which to evaluate the state of tissue oxidative metabolism. The opportunities afforded by other nuclei are being studied, but the low sensitivity of the MR technique forces limitations. Recent technical advances in tissue localization have as yet only been applied in a limited way. The use of MR in metabolic disease will be considered with specific reference to disorders of skeletal muscle metabolism.

Adenosine Triphosphate↗
PubMed1985

Total body potassium and water, and exchangeable sodium, in muscular dystrophy.

Total body potassium (40K method) and total body water and exchangeable sodium (both by isotope dilution) were determined in 26 boys, aged 5-17 years, with muscular dystrophy. Total body potassium values were compared with measurements in a large series of normal boys on the basis of height. Total body potassium was reduced even in the youngest patients and was only slightly higher in the older boys, despite their considerably greater height. Exchangeable sodium increased with increasing height in a way similar to that of normal boys. Total body water was also reduced but increased with growth, although to a lesser extent than expected for normal boys. The total body water measurements indicated that many of the affected boys were very obese, despite an apparently normal body weight. An intravenous bolus of 22Na distributed at a similar rate in boys with muscular dystrophy to that in normal males. In relation to the predicted values, total body potassium and 24 h urinary creatinine excretion of the affected boys both declined at a rate of 4% per year.

Adipose Tissue↗
PubMed1985

Topical magnetic resonance for the study of muscle metabolism in human myopathy.

The role of changes in energy metabolism are obvious in the myopathies with described enzyme defects, but the ability afforded by topical magnetic resonance spectroscopy to study these changes repeatedly and non-invasively helps provide an understanding of the alterations in energy metabolism seen in muscle complaints of which the aetiologies are still unclear. Attention is focused on interpreting the findings with particular regard to Duchenne muscular dystrophy.

Adult↗
PubMed1984

Weight reduction in boys with muscular dystrophy.

Many children with muscular dystrophy are overweight, and although weight control is pursued in some centres it is unusual to encourage severe dietary restriction for fear that it might lead to accelerated loss of muscle. In this study, two overweight boys with muscular dystrophy were monitored by whole-body nitrogen balance, total body potassium, strength and functional measurements during calorie restriction. Both patients were found to have a transient loss of nitrogen on commencing the low calorie intake: thereafter, weight loss was not found to have any deleterious effect on muscle bulk or function in either patient. It is suggested that controlled weight-reduction in obese children with muscular dystrophy is a safe and practical way of losing excess fat, which can improve mobility and self-esteem, and may possibly effect longevity.

Adolescent↗
PubMed1978

The influence of videotape feedback on the self-assessments of psychiatric patients.

The effects of videotape feedback on patients' self-perception were assessed in a study which was a partial replication of an investigation reported by Griffiths and Hinkson (1973). Subjects were randomly allocated to one of three groups. After a semi-structured interview, they were either (1) shown a videotape of the interview, or (2) shown a videotape of another person being interviewed, or (3) engaged in other activities not involving videotape. Patients' self-ratings indicated that videotape feedback has immediate effects on self-assessments of social ease and physical attractiveness. Feedback produced changes in ratings of social ease, but individuals differed in the direction of the change (i.e. whether social ease was "better" or "worse"). The direction of the change was predicted by a questionnaire measure of response style. Feedback also tended to make patients rate themselves as less attractive in the eyes of other people. All changes were, however, temporary and had disappeared at a two-week follow-up. The results are generally consistent with those reported by Griffiths and Hinkson in that they indicate temporary and specific changes in response to videotape feedback. The implications of the results are discussed.

Adolescent↗
PubMed1977

The prediction of psychiatric patient's work adjustment in the community.

Five aspects of patients' work behaviour were assessed by supervisors in a rehabilitation unit. The assessments involved task competence, response to supervision, relationships with other patients, motivation and enthusiasm, and confidence-initiative. These assessments were compared with work adjustment after discharge, and also with intelligence, personality, chronicity and age. All aspects of work behaviour correlated with work success in the community. Predictions based on both the workshop and clerical assessments were very accurate, and the predictions of outcome were better for the clerical than the "manual" patients. Work behaviour was, in general, unrelated to intelligence, personality, age and chronicity, though there were specific exceptions to this trend. The theoretical and practical implications of these results are discussed.

Adult↗
PubMed1977

Direct assessment of social behaviour from videotape recordings.

A number of frequency and duration measures, and also general ratings, were made to assess specified aspects of interpersonal behaviour. These were taken from videotape recordings of interviews, or informal conversations, involving psychiatric patients. The frequency and duration measures were found to have high inter-rater reliability. Pearsonian correlations were in the range of 0-88--0-99. The general ratings were less reliable (0-42--0-86). The patients were divided into two groups. The first were patients whose major difficulties were interpersonal problems. The second contained patients with other psychiatric problems. Comparisons between these groups revealed a number of significant differences in the behavioural frequency and duration measures. Significant differences were also found in the general ratings, but there were disagreements between the two raters which made the interpretation of these differences difficult. When, within the interpersonal problem group, informal conversations were compared with formal interviews, it was found that subjects spent longer looking at the other person during the conversation. No other differences were evident. The implications of the results for social skills research are discussed.

Adult↗
PubMed1975

The accuracy and correlates of psychiatric patients' self-assessment of their work behaviour.

A preliminary study demonstrated that psychiatric patients' evaluation of their work behaviour was unrelated to assessments made by experienced supervisors. Patients involved in clerical work were shown to be more accurate in self-assessment than patients in the manual assembly section of a rehabilitation unit; clerical patients underestimated, and manual patients overestimated their performance. These findings were confirmed in a second study, which also identified some of the differences between the 'clerical' and 'manual' groups, and showed that underestimation was associated with higher intelligence, a general tendency to admit to undesirable behaviours, and a relatively long period of contact with psychiatric services. Neuroticism was also related to underestimation, and schizophrenic patients overestimated their performance. Work satisfaction was found to be unrelated to work performance.

Adult↗
PubMedDate not supplied

Muscle energy metabolism in Duchenne dystrophy studied by 31P-NMR: controlled trials show no effect of allopurinol or ribose.

31P nuclear magnetic resonance (NMR) was used to investigate the resting energy metabolism of the calf muscle in boys with Duchenne's muscular dystrophy. Reductions in the phosphocreatine/adenosine triphosphate (PCr/ATP) and the PCr/Pi ratios were found, but ATP as a fraction of the total mobile phosphorus signal was not reduced, and intracellular pH was normal in the Duchenne muscle. Attempts at quantitation of the NMR signal suggested that the reduced total phosphorus signal seen in the Duchenne muscle was a result of muscle fiber loss only and that the muscle fiber ATP concentration was probably normal in the diseased tissue. An exercise study in one 7-year-old boy with Duchenne's dystrophy demonstrated that the muscle had a normal ability to break down and resynthesize phosphocreatine. Presented here are the first reported trials of the effects of two putative therapeutic agents on energy metabolism determined by NMR in Duchenne's muscular dystrophy.

Adolescent↗