Biomedical subjects

R D Kissun

Publications and source records attributed to R D Kissun.

15 recordsLinked to original sources

PubMed1989

Endothelial cell-stimulating angiogenesis factor in vitreous from extraretinal neovascularizations.

The presence of endothelial cell-stimulating angiogenic factor (ESAF) in diseased human vitreous humour has been established. The molecular mass and chromatographic behavior of this material and its property of activating procollagenase indicate it to be identical to the ESAF isolated from other sources. The biological activity of ESAF from human vitreous was demonstrated by its ability to induce positive responses in the rabbit corneal pocket, and in the chick chorioallantoic membrane and yolk sac membrane tests.

Angiogenesis Inducing Agents↗

PubMed1988

Increased procollagenase activating angiogenic factor in the vitreous humour of oxygen treated kittens.

Previous studies have demonstrated an increase in a low molecular weight angiogenic factor (ESAF) present in the retinae of kittens with oxygen induced retinopathy. The present paper describes differences in the quantity of ESAF extracted from the vitreous humour of control and oxygen treated animals and proposes a mechanism for the induction of intravitreal neovascularisation.

Angiogenesis Inducing Agents↗

PubMed1986

Effect of oxygen tension on the quantities of procollagenase-activating angiogenic factor present in the developing kitten retina.

Maintenance of newborn kittens in an oxygen rich atmosphere followed by a recovery period in a normal atmosphere mimicked the effects of the human disease retrolental fibroplasia. The retinas of such kittens contained significantly raised levels of low molecular weight angiogenic material (as measured by procollagenase activation) when compared with those of a control group of kittens.

Angiogenesis Inducing Agents↗

PubMed1983

Angiogenic factor in vitreous from diabetic retinopathy.

Vitreous from patients with proliferative diabetic retinopathy contains an angiogenic substance which stimulates the proliferation of blood vessels on the chick chorioallantoic membrane, whereas vitreous from non-diabetics who do not have a proliferative retinopathy does not.

Allantois↗

PubMed1983

Partial galactose disorders in families with premature cataracts.

Minor and major deficiencies of enzymes affecting galactose metabolism may be associated with cataracts of early onset. Results are presented for 10 such families with minor enzymatic disorders. Expression of the major disorders probably involves galactitol accumulation and osmotic lens damage but this mechanism is not obviously associated with minor disorders. The observed incidence of minor incomplete enzymatic disorders of galactose metabolism in families with an incidence of cataracts of early onset may be at least partly incidental.

Adolescent↗

PubMed1982

A low-molecular-weight angiogenic factor in cat retina.

A low-molecular-weight angiogenic factor has been isolated from healthy adult cat retinas. The factor, which has been purified by diethylaminoethyl (DEAE) cellulose chromatography and affinity chromatography, stimulates neovascularisation of the chick chorioallantoic membrane and has a number of properties similar to those previously described for a tumour factor. The finding of an angiogenic factor in healthy retina and its relationship to previously described inhibitors of angiogenesis is discussed.

Angiogenesis Inducing Agents↗

PubMed1982

Galactose intolerance and the risk of cataract.

Cataracts may arise in association with various major and minor disorders restricting galactose metabolism, and the risk is broadly associated with the degree of galactose intolerance. A family is described in which a girl presented at the age of 7 3/4 years with cataracts, galactosuria, and partial deficiencies of the enzymes galactokinase and galactose-1-phosphate uridyl transferase. Galactose intolerance as determined by an oral test was impaired and fluctuated with variation in activity of the above galactose enzymes. Minor defects were also present in the parents and a maternal half-brother. The child has a compound disorder of galactose metabolism differing from those previously described. Assessment of galactose tolerance may be useful in the investigation of families with an incidence of cataract.

Carbohydrate Metabolism, Inborn Errors↗

PubMed1980

Ocular angiogenesis in disease states.

Other contributors to this symposium will concern themselves with the stimulus to angiogenesis. My role is to review the character and topography of neovascularization with the eye. It would be redundant, however, if I were merely to recount the morphology of ocular new vessels and their location and not, in the process, draw attention to facets which may provide a clue to their pathogenesis and to attempt some sort of clinico-pathological correlation. This synopsis is confined to pathological angiogenesis involving the retina, iris, and cornea. Preretinal neovascularization alone will be discussed, since other papers will examine the intra-and subretinal locations.

Child↗

PubMed1977

Vasoformative properties of normal and hypoxic retinal tissue.

By cannulating the stroma of rabbit corneae, and introducing extracts of retina and vitreous from newborn kittens subjected to vaso-obliterative doses of oxygen, an attempt was made to test the hypothesis that ischaemic retinal tissue releases a factor with vasoformative properties. It was found that, although retino-vitreal extracts from the test animals elicited a positive response in just over half the experiments, the degree of corneal vascularisation provoked by extracts from intact control animals was only marginally less. Consequently our findings do not permit any definite answer regarding the existence of a specific factor responsible for the proliferation of new vessels on the retinal surface in states associated with retinal hypoxia.

Animals↗

PubMed1976