Biomedical subjects
Publications and source records attributed to R D Ligorsky.
Sweet's syndrome is an acute febrile neutrophilic dermatosis. A wide variety of systemic signs and symptoms have been associated with it, but pulmonary involvement has been noted in only one previous report. Additionally, although Sweet's syndrome has been frequently associated with various malignancies, there is only one previous case reported with attendant chronic myelogenous leukemia.
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Acute myelomonocytic leukemia occurred in a 69-year-old man with malignant lymphoma and macroglobulinemia. Fluorescent staining demonstrated the macroglobulin in plasma and leukemic cells. Plasma cells seemed to be producing paraproteins, while leukemic cells appeared to be engulfing them as seen with transmission electron microscopy. The sequence of events ruled out the possibility that myelomonocytic leukemia developed following the use of cytotoxic drugs. The case presented in this report is a rare example of malignant lymphoma, macroglobulinemia, and acute myelomonocytic leukemia occurring in the same patient.
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