1. The blood-bathed organ technique was used to assay the concentration of angiotensin in the blood of anaesthetized dogs.2. Alterations of blood volume caused inverse changes of angiotensin concentration owing to changes in the rate of generation of angiotensin which are probably due to changes of the rate of renin secretion.3. Haemorrhage of 14-26 ml. blood/kg caused an increase of 0.25-1.5 mug/min in the rate of generation and an increase of 0.1-0.33 ng/ml. in the blood concentration of angiotensin.4. The changes of angiotensin generation rate were not due to changes of renal arterial or venous pressure. They were abolished by blocking the renal nerves with lignocaine; they showed a consistent inverse correlation with central venous pressure but not with systemic arterial pressure.5. It is concluded that changes of blood volume bring about changes of the rate of generation of angiotensin by a reflex mechanism the efferent limb of which involves the renal nerves. The afferent pathway remains to be elucidated, but the systemic baroceptors do not appear to be of primary importance.6. The renin-angiotensin system is important in the homeostatic response to changes of blood volume.

Angiotensin II↗

PubMed1966

Effect of sympathomimetic compounds with beta-adrenergic effects on plasma free fatty acids in man.

Nine sympathomimetic compounds were infused intravenously in man, and their effects on the level of plasma free fatty acids, pulse rate, and blood pressure were recorded. Each compound raised the level of plasma free fatty acids. Its activity in this respect could be correlated with its activity in producing Beta-adrenergic effects on the circulation; both effects were abolished by pretreatment with propranolol. It is concluded that sympathomimetic compounds that stimulate -receptors will raise the plasma concentration of free fatty acids.

Fatty Acids↗

PubMed1966

A constant pressure variable flow blood perfusion system.

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Blood Flow Velocity↗