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R D Lund

Publications and source records attributed to R D Lund.

197 records · Page 11Linked to original sources
PubMed1971

Synaptic adjustment after deafferentation of the superior colliculus of the rat.

Eyes were removed from rats shortly after birth, when there are few formed synapses in the colliculus. It was found that synaptogenesis continues to give a near-normal ratio of terminals containing either spheroidal or flattened vesicles. After eye removal in adult rats, however, reinvasion of synaptic sites vacated by degenerate optic terminals occurs, with an incomplete return toward a normal proportion of synaptic types.

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PubMed1966

Neurofibrils and the Nauta method.

When the pretreatment stages are omitted, the Nauta method for degenerating axons stains neurofibrils. Under the electron microscope the stain is closely related to neurofilaments. When one uses the comnplete Nauta technique, the stain is specific for mnembrane structures.

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PubMedDate not supplied

Unilateral photoreceptor rescue can improve the ability of the opposite, untreated, eye to drive cortical cells in a retinal degeneration model.

In the Royal College of Surgeons, rat photoreceptor degeneration occurs over the first several months of life, causing deterioration of visual cortical responsiveness seen as greater numbers of cells being nonresponsive to visual stimulation, poor tuning of those cells that do respond, and an overall tendency for domination by the contralateral visual input. If the progress of degeneration in one eye is slowed by intraretinal cell transplantation, cortical responses to stimulation of the remaining, untreated, eye are much stronger, better tuned and histograms of ocular dominance resemble more those in normal rats. This suggests that the rescued eye is able to enhance performance in the untreated eye by some form of postsynaptic mechanism.

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