Biomedical subjects

R D Schmitt

Publications and source records attributed to R D Schmitt.

3 recordsLinked to original sources

PubMed1996

EMBASE remains EMBASE--on every host? A comparative analysis of EMBASE on the hosts DATA-STAR, DIALOG, DIMDI, and STN.

Differing results of the same search request processed on different hosts led the authors to investigate this issue more thoroughly. Two authors, two journal titles, two drug names, and two topics of a general medical nature were retrieved under identical circumstances and conditions on the hosts DATA-STAR, DIALOG, DIMDI, and STN. Comparing the figures revealed that none of the nine search request produced an identical result on all hosts. Some of the search results differed only slightly, while the searches in the basic index produced considerable discrepancies.

Databases, Bibliographic↗

PubMedDate not supplied

Tolerance setting process in the U.S. Environmental Protection Agency.

The U.S. Environmental Protection Agency (EPA) is responsible for setting tolerances for pesticide residues in food, under the authority of the Federal Food, Drug, and Cosmetic Act. The residue chemistry data required to set tolerances include metabolism in plants and animals, analytical methods, magnitude of the residue, and concentration in processed foods. A key aspect of tolerance-setting procedures is the identity of the residue in the matrix of concern; without knowledge of the chemical moieties that occur as residues, it is impossible to develop suitable methods or generate meaningful residue data. For new chemicals, EPA carries out a single-laboratory validation of the analytical method needed to generate residue data and to enforce tolerances. Tolerance enforcement methods need to be rapid and inexpensive and to use commercially available equipment and reagents. Methods are more complex for many newer pesticides, which are polar compounds that leave low levels of residue. EPA now requires that the registrants of older pesticides, for which methods are not acceptable by today's standards, must develop better methods.

Animal Feed↗

PubMedDate not supplied

Residue chemistry guidelines.

Residue chemistry guidelines are designed to determine what the potential residues in food are and how much may be present as a result of pesticide application, so that a tolerance level may be established. Some requirements are established to assist in the enforcement of tolerances by the USDA, FDA, and the states. I realize I have given you a quick overview of the residue chemistry requirements. There are many documents which are available if you should require more information, such as the Subdivision O Residue Chemistry Guidelines, Standard Evaluation Procedures (which are used by reviewers when evaluating the studies), the Data Reporting Guidelines (which provide guidance on preparing final reports), and the Technical Guidance from Phase III of Reregistration. We have also released various papers on studies when additional guidance is required. Most of these documents are available from NTIS. I hope you will consider this information when auditing residue chemistry studies. As I see the efforts that you, the QA professionals, have made to educate yourselves on residue chemistry studies through programs such as this meeting, I have a little more confidence in answering the question "Do you trust them?" with a "Yes." Thank you.

Data Collection↗