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R D Sinclair

Publications and source records attributed to R D Sinclair.

33 records · Page 2Linked to original sources
PubMed1994

The basement membrane zone of the nail.

The anatomy of the epidermis, dermis and subcutaneous tissues of the nail apparatus is distinct from that of non-appendageal skin. Apart from the demonstration of the longitudinal configuration of the dermal-epidermal junction of the nail bed, there have been no studies of the composition of the basement membrane zone of the nail apparatus. We obtained three human accessory digits, including one thumb, all of which had been amputated for cosmetic reasons, and were without known pathology. Specimens were stained with a battery of monoclonal and polyclonal antibodies which target normal basement membrane zone antigens, and studied by indirect immunofluorescence. This study demonstrated that the four distinct regions of the nail, namely the proximal nail fold, the nail matrix, the nail bed and the hyponychium expressed all the target antigens found in the normal non-appendageal basement membrane. In particular, there was normal expression of the epidermal-associated antigens, the 220- and 180-kDa bullous pemphigoid antigens, and the alpha 6 beta 4 integrin. There was also normal expression of the lamina lucida antigens LH39, GB3 and laminin. It is of interest that the dermal-associated components, namely the 285-kDa linear IgA antigen, the extracellular matrix glycoproteins chondroitin sulphate, type VII collagen and its closely associated proteins, and the poorly characterized antigen for LH24 and LH39 were all normally expressed. Fibronectin, which is not a normal basement membrane zone component, was diffusely expressed in the extracellular matrix, but did not accentuate the basement membrane zone.(ABSTRACT TRUNCATED AT 250 WORDS)

Antibodies, Monoclonal↗
PubMed1994

Proteolytic enzymes in wound healing: the role of enzymatic debridement.

Proteolytic enzymes are a family of proteins that serve to degrade necrotic debris derived from cell breakdown. They are produced endogenously often as precursor proteins whose activation is precisely regulated. These activated enzymes serve many functions in normal as well as pathological situations. In particular they are involved in the regulation of cell maturation and multiplication; collagen synthesis and turnover; the development and removal of the perivascular fibrin cuffs found in venous insufficiency and leg ulceration as well as the removal of dead tissues following inflammation. As a limited number of enzymes perform all these functions, it is difficult to predict the effects of applying synthetic proteolytic enzymes to a wound. Many such enzymes are currently commercially available and being promoted as alternatives to surgical wound debridement. It is important for their use to be considered in the context of their interaction with endogenous proteases, their physiological role in tissue, their ability to reach a desired target and the stage of wound healing at the time they are applied.

Cell Division↗
PubMed1992

Congenital inclusion dermoid cysts of the scalp.

The natural history of congenital inclusion dermoid cysts of the scalp is unknown. We report three cases of this condition, which has been followed from birth for up to ten years. Dermoids are congenital subcutaneous cysts, which gradually flatten and scar over a number of years. The lesions are covered with skin showing focal alopecia but they may be surrounded by a collar of hypertropic hair. Later in life flattened cysts may be mistaken for aplasia cutis, but the history of a cyst at birth allows the clinician to distinguish these two conditions. As these cysts have a potential for intracranial extension, this is an important clinical entity.

Alopecia↗
PubMed1980

Chemical and nonchemical components of ventilation during hypercapnic exercise in man.

Nine young athletes performed treadmill exercise at average VO2 levels of 1.08, 1.78, 3.00, and 3.57 l/min while exposed to inspired PCO2 levels of 0, 10, 20, 30, and 40 Torr. The average slope of the VE-PACO2 relationship increased significantly from 3.59 to 4.70 l.min-1.Torr-1 in the transition from rest to light exercise and then decreased progressively and significantly to 1.34 l.min-1.Torr-1 at the highest work load. A similar pattern of initial increased steepness followed by progressive flattening was found in the VT-PACO2, curves, whereas slopes of the f-PACO2 relationships continuously decreased in the transition from rest through light to heavy exercise. These data are consistent both with an increased ventilatory response to PACO2--[H+]a increments during light exercise and with progressive reduction of that response during the transition from light to heavy exercise in parallel with increasingly severe mechanical influences on VE as maximal limits are approached. They are not consistent with simple addition of chemical and nonchemical components of exercise hyperpnea at all levels of exercise.

Acid-Base Equilibrium↗
PubMedDate not supplied

Hirsuties.

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Female↗