PubMed Health⌕ Search

Biomedical subjects

R Dang

Publications and source records attributed to R Dang.

7 recordsLinked to original sources
PubMed1998

Multiple myeloma in three siblings.

There have been 53 reported instances of myeloma occurring in more than one family member but in only three of these reports have three siblings been affected (Alexander & Benninghoff 1967; Maldonado & Kyle 1974; Horwitz et al. 1985; Crozes-Bony et al. 1995). We report a family where three siblings had an unequivocal diagnosis of myeloma made over a period of six years. The paraprotein isotype was IgG kappa in two of the siblings and kappa light chain only in the remaining sibling. The importance of these cases lies in the fact that they are highly suggestive of a genetic predisposition to the development of myeloma. Because of the high prevalence of p53 abnormalities in certain types of familial cancer screening for p53 mutation in exons 5-8 was performed by denaturing gradient gel electrophoresis (DGGE) on DNA extracted from the bone marrow of the three siblings. Although a p53 mutation was identified in one of the siblings it was felt to represent a somatic as opposed to a germline mutation.

Aged↗
PubMed1988

Cannabis and cognitive functions: a prospective study.

Psychological tests measuring intelligence, memory and other cognitive functions were given to 26 heavy cannabis users (mean duration of cannabis use 6.76 years; average daily intake 150 mg THC). Compared with a control group, the cannabis users were found to react slowly in perceptuo-motor tasks, but not to differ in intelligence or memory tests. The users suffered disability in personal, social and vocational areas and indicated higher psychoticism and neuroticism scores.

Adolescent↗
PubMed1987

Biochemically damaged erythroblasts bind natural serum antibodies and activate complement.

Friend leukaemia erythroblasts which had been damaged biochemically by treatment with inhibitors of cellular metabolism (sodium fluoride, sodium azide) or of protein synthesis (cycloheximide, puromycin) were incubated with heat-inactivated or fresh mouse serum and tested for surface-bound IgG and C3c, respectively, by reaction with FITC-immunoconjugates followed by flow-cytofluorometry. Erythroblasts exposed to sodium azide, cycloheximide or puromycin showed specific binding of IgG; the extent of binding was related to the concentration of the drugs and duration of treatment. Moreover, prolonged exposure of the cells to the inhibitors of protein synthesis lead to a dose-dependent activation of complement. The results suggest that the opsonization of biochemically-damaged Friend leukaemia erythroblasts with IgG and C3 may facilitate their interaction with macrophages.

Antibodies, Anti-Idiotypic↗
PubMed1980

Non-medical drug use amongst non-student youth in India.

In a survey of non-medical drug use by 266 non-students in the age range 10-24 years, tobacco, alcohol and cannabis were found to be the drugs more commonly used. Use was greater in males, older age groups, those with lower educational levels and those from urban areas. In comparison to students, among non-students use was practically limited to tobacco, alcohol and cannabis, the use was more regular and the age at onset lower. In a pilot trial of two additional strategies to identify drug users among non-student youth, namely cross-validation by fellow employees and verbal group administration of the questionnaire, the number of current users identified was very similar to that found by individual verbal administration, suggesting that these cheaper methods may be useful in some circumstances.

Adolescent↗
PubMedDate not supplied

Anatomic considerations in relation to the maxillary nerve block.

BACKGROUND AND OBJECTIVES: To determine the length of the needle that should be used to reach the maxillary nerve after the lateral pterygoid plate has been contacted. METHODS: The study was conducted on patients and skulls. Patient study: The distances from skin at the midpoint of lower border of zygomatic arch to lateral pterygoid plate and to the point where a paresthesia in the distribution of maxillary nerve was obtained were measured in 75 patients. Osteologic study: The distance from the midpoint of lower border of zygomatic arch to lateral pterygoid plate and to a probe inserted from the orbital aspect through the inferior orbital fissure and pterygopalatine fossa into the foramen rotundum (representing maxillary nerve) was measured in 120 skulls. RESULTS: Patient study: The distance to the point where paraesthesia occurred was more than that to the lateral pterygoid plate by 0.21 cm on the right side and 0.22 cm on the left side. Osteologic study: The distance to the probe in the pterygopalatine fossa was more than the distance to lateral pterygoid plate by 0.13 cm on the right side and 0.14 cm on the left side. CONCLUSIONS: The needle should not be advanced by more than approximately 0.25 cm beyond the distance to the pterygoid plate while performing maxillary nerve block by the lateral extraoral approach.

Adult↗
PubMedDate not supplied

Anatomic considerations in relation to the mandibular nerve block.

OBJECTIVES: To determine the length of needle that should be advanced beyond the distance to the lateral pterygoid plate to reach the mandibular nerve. METHODS: The study was conducted on patients and skulls. PATIENT STUDY: Distances from the skin at midpoint of the zygomatic arch to lateral pterygoid plate and to the point where mandibular nerve paraesthesia occurred were measured in 74 patients having mandibular nerve block for treatment of neuralgic pain. Osteologic study: Distances from the midpoint of the zygomatic arch to lateral pterygoid plate and to a probe inserted vertically into the foramen ovale were measured in 76 dry skulls. RESULTS: Patient study: The distance to the point where mandibular nerve paraesthesia occurred was more than that to lateral pterygoid plate by 0.07 cm on right and 0.11 cm on left. Osteologic study: The distance to the probe in the foramen ovale (representing mandibular nerve) was less than the distance to lateral pterygoid plate by 0.08 cm on the right and 0.07 cm on the left. CONCLUSIONS: There is no osteologic basis to advance the needle beyond the distance to the lateral pterygoid plate to reach mandibular nerve. However, because the needle may contact the nerve at variable points rather than the shortest distance to the nerve, the needle may be advanced by 0.07 cm on the right and 0.11 cm on the left side in patients. This increase is much less than that indicated in the standard textbooks. Therefore, while performing mandibular nerve block, we suggest caution in advancing the needle beyond the distance to lateral pterygoid plate.

Adult↗