[Surgical treatment of chronic calcifying pancreatitis].
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Biomedical subjects
Publications and source records attributed to R Dani.
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The analysis of 92 proved cases of chronic calcifying pancreatitis showed that 82 were males and 10 were females. Seventy-five out of the 92 patients were chronic alcoholics with a mean age of 38.2 years at the onset of symptoms and with a predominance of males over females (72:3). For the 17 non-alcoholic patients the mean age at the onset was 26.4 years, with almost the same number of males and females (10:7). The differences in age and sex suggest that different factors are responsible for the pathogenesis of the disease. Clinical, surgical and anatomical features of chronic calcifying pancreatitis are discussed. The incidence of pancreatic carcinoma in our patients is higher than in the general population.
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Two hundred and sixty two patients with gallbladder stones were prospectively evaluated at the Biliary Lithiasis Treatment Unit of the Mater Dei Hospital, Belo Horizonte, MG., and 45 (17.5%) were selected for extracorporal shock wave lithotripsy (ECSWL). From these, 32 were submitted to the procedure. One stone was present in 30 patients, 2 stones in another and 1 patient had 3 stones. The mean diameter was 14.7 mm ranging from 8 to 28 mm. ECSWL was preceded by 1 week course of ursodeoxycholic acid (8 to 10 mg/dk/day) and this medication was continued after the procedure. ECSWL was done with the Lithosthar-Plus apparatus (Siemens). Meperidine (up to 100 mg) IM and pirazolene IV was given when necessary. The intensity of the shock waves was gradually increased to a maximum (9 bar) whenever tolerated. The treatment was well succeeded in 22 cases (71%) with pulverization in 12 (38.7%). In 9 patients (29%) remaining fragments were greater than 4 mm. From these, 3 were submitted to a second session of ECSWL. In 1 patient the stone could not be properly positioned for lithotripsy. The mean number of shock waves was 2,591, ranging from 801 to 4,411. The mean duration of the sessions was 80 min, ranging from 45 to 150 min. In 3 patients, a complete disappearance of fragments was observed in intervals of 1 to 6 months after the procedure. One patient had severe pain during ECSWL and developed acute cholecystitis. One patient had sinus bradycardia. One patient with total stone pulverization, become jaundiced 1 month after ECSWL and a gallbladder carcinoma was found at surgery.(ABSTRACT TRUNCATED AT 250 WORDS)
A total lyophilized pig pancreas (TLP) preparation was assayed "in vitro" and "in vivo". Lipase activity of the four lots studied was 6.180 +/- 1.122 IU by gram of the commercial product. There was no free trypsin detectable in the preparation. Fifteen pancreatic exocrine insufficiency patients were studied in a period of four weeks. Adult patients received from 35.500 to 35.776 IU of lipase contained in TLP preparation by meal. All patients had their steatorrhea reduced, or normalized, stool weight reduced and body weight increased. There is not an obligatory relation between stool fat loss and stool weight. Steatorrhea decreased at least during the 14 first days of treatment before reaching a stable level. This long delay before reaching a maximum effect deserves to be known: to test the efficiency of a pancreatic extract, the treatment must be given at least two weeks before estimating its results on fecal fat excretion.
Seventy-eight consecutive patients (mean age 59 years) have been submitted to concomitant liver biopsy with Menghini and Chiba needles. The same place in the liver was reached by both needles. In 54 cases there was a clinical suspicion of malignancy and in 24 patients biopsy was indicated by other reasons. In 60 cases the biopsies were oriented by laparoscopy. Comparing the results attained by Menghini needle ("gold standard") and the results of the cytologic study of the material obtained with Chiba needle, the last method has proved to be sensible (92.7%), specific (97.3%) and reliable (accuracy = 94.9%).
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One-hundred cases submitted to percutaneous transhepatic cholangiography (PTC) with Chiba's needle were studied. Success rate was 93%, with 100% success in patients with dilated ducts and 78.8% in those with normal ducts. One false-positive result was noticed due to air injection into bile duct in the beginning of the procedure. Complications were seen in 8 cases, without fatalities ascribed to the PTC itself, nor emergency laparotomy was necessary in these cases.
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Sixty patients with chronic calcifying pancreatitis (CCP) of alcoholic etiology have been submitted to liver biopsy: in 44 cases the fragment was obtained during surgery, in four cases under laparoscopy, in five during necropsy, in two blind percutaneous biopsy and both surgical and laparoscopic in two cases. Cirrhosis was demonstrated in eight patients (13,3%). The authors emphasises the necessity in patients with alcoholic CCP.
Determinations of histocompatibility antigens of A and B loci was undertaken in 22 white male patients with chronic calcifying pancreatitis (CCP) of alcoholic etiology and compared to 100 controls. Results were analysed by the kappa2 test with Yates correction. HLA--AW23 and AW24 were significantly more prevalent in patients than in controls and HLA-B8 was absent in all CCP cases. Although the small number of cases is insufficient to allow any definite conclusion, the obtained data suggests the presence of a genetic predisposition to this disease.