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Biomedical subjects

R Danner

Publications and source records attributed to R Danner.

At least 37 records · Page 2Linked to original sources

Unilateral thenar hypoplasia.

This report documents a patient with unilateral hypoplasia of the thenar eminence. The clinical, electrodiagnostic, and radiological findings indicated a developmental abnormality which must be considered in the differential diagnosis of carpal tunnel syndrome.

Adult↗

Electroneuromyographical and morphological findings in progressive myoclonus epilepsy (PME).

The purpose of this study was to assess the function of peripheral nerves and muscles and to describe morphological changes in muscle biopsies of patients with progressive myoclonus epilepsy. Electroneuromyographic studies were performed on 24 adult patients whose mental and motor skills were either little, moderately or severely impaired by the disease. In 5 patients a specimen of tibial anterior muscle was morphologically and histochemically investigated. The electrophysiological functions of the peripheral nerves and muscles showed gradual increasing abnormalities parallel to the severity of clinical deterioration. The muscle biopsies of 2 patients showed signs compatible with peripheral neuropathy. These findings suggested that progressive myoclonus epilepsy may be related to a systemic membrane disorder.

Adolescent↗

[The sensory-integrative process and its influence on child development (author's transl)].

A child develops and learns skills by interacting with his environment. Play provides him with the sensory stimulation his brain needs in order to be able to allow him to respond in a meaningful way to these stimuli. Until the age of seven the brain is thus prepared for the challenges of the classroom. The neurologic problem in the child with a sensory integrative dysfunction prevents him from processing the sensations of his own play, so he cannot develop the adaptive responses that organize the brain and his actions. This child needs a specially designed environment in order to experience joy and satisfaction during his play, that allow him to learn higher skills and organize the brain functions. The purpose of this article is to clarify what sensory integration is and how it influences the child's development.

Attention Deficit Disorder with Hyperactivity↗

Fibrillation potentials after muscle injury in humans.

To study the occurrence and firing pattern of fibrillation potentials, electromyographic recordings were made on 43 patients after a small muscle injury caused by conchotome biopsy or intramuscular injection. The fibrillation potential sequences were manually evaluated from paper records. At 6 to 7 days after the muscle biopsy, most subjects showed fibrillation potentials with gradually increasing or decreasing discharge intervals of 70 to 3,200 msec. Several irregular fibrillation patterns were observed 9 or more days after biopsy. Fibrillation potentials appear to be generated by at least three mechanisms in humans.

Action Potentials↗

Chronic anticonvulsive therapy, peripheral nerve conduction velocity, and EMG.

Chronic, mentally subnormal epileptic patients were clinically and neurophysiologically studied in order to determine the occurrence and type of peripheral nerve dysfunction. We observed significant impairment of motor and sensory nerve conduction velocities and H-reflex latencies. Amplitudes of sensory and motor responses were diminished. Motor distal latencies were not prolonged. Conclusive EMG signs of active denervation were not observed. The possible role of anticonvulsive treatment as an underlying noxa is discussed.

Adult↗

Electrophysiological signs of peripheral nerve dysfunction in progressive myoclonus epilepsy.

Electrophysiological findings were analysed in a group of 24 patients with progressive myoclonus epilepsy (PME) without Lafora bodies. Denervation activity in needle EMG and diminution of motor and sensory responses pointed out a mild axonal degeneration. We observed a significant slowing of motor and sensory conduction velocities in all the limb nerves examined, but distal motor latencies were not significantly increased. H-reflex latency of the posterior tibial nerve was prolonged. These results yielded the suggestion that there is a systemic peripheral nerve membrane dysfunction in PME.

Adolescent↗

[Measurements of nerve conduction velocity during decreasing toxic diphenylhydantoin levels and the beginning of carbamazepine medication. A clinical neurophysiological documentation (author's transl)].

Sensory and motor nerve conduction velocity was determined daily in an epileptic patient during recovery of acute diphenylhydantoin toxicity and at the beginning of carbamazepine medication. A statistical correction, which accounts for the influence of variable skin temperatures on the sensory nerve conduction velocity (SNCV), proved to be useful for SNCV measurements of the sural nerves. We found significant correlation between the increasing sensory nerve conduction of the sural nerves and the decreasing diphenylhydantoin levels. During rising carbamazepine concentrations, we observed decreasing conduction velocities in peripheral nerves.

Carbamazepine↗

Schistosoma mansoni and S. haematobium infections in Egypt. IV. Hepatic lesions.

We performed 400 consecutive autopsies in Cairo, Egypt. The intensity of schistosome infection in these cases was measured by counting adult worms recovered by perfusion and dissection and by counting eggs in the tissues of infected cases. Symmers' clay pipestem fibrosis of the liver was clearly related to the presence and intensity of Schistosoma mansoni, but not S. haematobium, infection. Morphologic findings in cases with Symmers' fibrosis were comparable to those in Brazilian cases, and the intensity of S. mansoni infection associated with Symmers' fibrosis was similar in Brazil and Egypt. The fine bilharzial periportal fibrosis described by Hashem was not identified in our material, and Symmers' fibrosis was present in all cases of portal hypertension caused by schistosomiasis. Schistosome eggs were found concentrated in areas of portal fibrosis of cases with Symmers' fibrosis. In the absence of Symmers' fibrosis, eggs did not concentrate in large portal areas regardless of the intensity of infection or the presence of lesser degrees of portal fibrosis. We thus feel it unlikely that Symmers' fibrosis is formed by the fusion of fibrotic granulomas around the schistosome eggs.

Adolescent↗

Schistosoma mansoni and S. haematobium infections in Egypt. I. Evaluation of techniques for recovery of worms and eggs at necropsy.

Four hundred consecutive autopsy cases were examined in Cairo, Egypt. Sixty percent of cases had Schistosoma haematobium eggs in the tissues and 25% also were infected with S. mansoni. Only a quarter of S. haematobium infections were active, while nearly two-thirds of S. mansoni cases remained active. Adult S. haematobium and S. mansoni were effectively recovered from the mesenteric circulation by a combination of perfusion and dissection. Quantitative recovery from the genitourinary system was reasonably complete, although small numbers of worms were missed in the dissection of these organs.

Adolescent↗