Biomedical subjects
R De Carlo
Publications and source records attributed to R De Carlo.
Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity.
The synthesis of isonicotinic, nicotinic and clofibric esters (III a, b, c) and (IV a, b, c) starting from N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)-1,3,3-trimethylbicyclo [2.2.1] heptan-2-endo-amine is described. In general these esters showed a normolipemic activity in rats; in particular, the isonicotinic ester (IV a) showed a hypocholesterolemic activity higher than that of clofibric acid.
In vitro effect of reproterol upon pulmonary, cardiac, vascular and intestinal 3',5'-monophosphate phosphodiesterase nucleoside.
Explore the source record for details and available documents.
Derivatives of 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2.] nonane with antiarrhythmic, local anesthetic and hypotensive activities. III.
The synthesis of alkyl and aryl ureas (II) derived from 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2.]nonane (I), as well as hydrazides (V), (VI) and (VII) derived from 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]-nonan-3-amine (IV), is described. A number of theses compounds showed strong hypotensive and bradycardic activities in rats, as well as weak infiltration anesthesia and antiarrhythmic activity in mice. Antiacetylcholine activity in vitro is also reported.
Interactions between inosine and adenosine: experimental researches.
Experimental investigations have shown that inosine enhances purinergic reactivity. This was examined with adenosine at the level of the cardiovascular, intestinal and uterine musculature. The mechanism of this activity may probably be inhibition of uptake without significantly altering serum adenosinase.
[CEA as a marker in primary and secondary pulmonary tumors].
Explore the source record for details and available documents.
Nutritional and metabolic effects of some newer steroids. VI. Serum ribonuclease.
Explore the source record for details and available documents.