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Biomedical subjects

R De Simone

Publications and source records attributed to R De Simone.

89 records · Page 5Linked to original sources
PubMed1989

[A computerized system for the management of clinical data in a cardiology service].

The authors describe a computerized system for medical records built in order to obtain rapid information about the data of the overall patients and to quickly manage the clinical research of the Institution. The hardware, an Olivetti M 19 personal computer with a 10 Mbyte hard disk, can manage the clinical data on 3000 patients or more; the software, DBase III Plus, by Ashton-Tate, has a programming language easy to use, even by non-experts. The system allows immediate statistical analysis of all patients and of all 350 parameters included in the database.

Database Management Systems↗
PubMed1988

Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study.

An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis of migraine has been performed in 70 children. After 4 weeks of medication-free base-line observation, 35 children (group A) received flunarizine (5 mg/day) and 35 (group B) received placebo over a 12-week period. After a 4-week washout they crossed treatments for another 12 weeks. Sixty-three patients completed the trial. In both groups flunarizine significantly reduced the frequency and average duration of headache attacks. In group A efficacy was maintained after placebo crossover for the last 4 months of the study. Five subjects in group B stopped placebo because of ineffectiveness; two children in group A discontinued flunarizine treatment, one because of excessive daytime sedation and the other because therapy was ineffective. The main side effects were daytime sedation and weight gain. It is concluded that flunarizine is an effective drug for the treatment of childhood migraine. In a study of this length no serious side effects were discovered.

Child↗
PubMed1978

New microporous cholestyramine analog for treatment of hypercholesterolemia.

A new, microporous, uniformly reticulated preparation of cholestyramine is described. The preparation, cholpor, has a higher exchange capacity for chloride than does cholestyramine and swells very little in water. It is 15--20% more potent than chloestyramine in the in vitro binding of sodium cholate; moreover, the binding velocity is considerably higher than that of cholestyramine. Colestipol hydrochloride, also used as a reference anion-exchange resin, is about half as potent as the other two resins; its binding velocity is similar to that of cholpor. Cholpor may be prepared in a suspension form of good palatability. Preliminary clinical findings in short-term trials showed a cholesterol-lowering effect similar to that of cholestyramine with lower doses and fewer side effects.

Adult↗
PubMedDate not supplied

[Neurological complications of schistosomiasis].

The authors describe the neurological complications of schistosomiasis, a widespread tropical infective disease. The neurological symptoms appear in an estimated 3 to 5% of patients; hence the importance for the general practitioner and the neurologist to consider this clinical entity in their practice.

Brain Diseases↗
PubMedDate not supplied

Prevalence of diabetes mellitus and of associated risk factors for atherosclerosis in a randomized population sample of western Sicily. Casteldaccia study.

Within the Targeted Programme of the Italian National Research Council "Preventive and Rehabilitative Medicine" subproject: Risk Factors, organized in nine centers on a national scale, the Operative Unit of Palermo carried out a transverse epidemiological study on a randomized population sample of western Sicily: Casteldaccia, 1984. 1.200 subjects subdivided by age in four decades (20-29; 30-39; 40-49; 50-59 years) and by sex (600 males and 600 females) were enlisted; the participation was 60.25% (No. 723; M = 364; F = 359). Following standardized procedures main cardiovascular risk factors were measured: glycaemia (GOD-PAP), triglycerides (enzymatic), total cholesterol (CHOD-PAP), HDL-cholesterol (MgCl2 dextran sulphate), apolipoproteins A1 and B (R.I.D.), B.M.I. (kg/m2), smoking habits and systolic and diastolic blood pressure (according to WHO manual on Cardiovascular Survey Methods). A questionnaire was used to record the familiar anamnesis, medical history of subjects, term of possible hyperglycaemia, current therapy (use of insulin, oral hypoglycaemic agent, dietetic treatment). The prevalence of diabetes mellitus was 8.16% (59/723): 4.67% (17/364) in males and 11.69% (42/359) in females. The most frequent risk factors associated with diabetes mellitus were; overweight (81%), hypercholesterolemia (49%), hypertriglyceridemia (45%), hypertension (37%) and cigarette smoking (15%).

Adult↗
PubMedDate not supplied

[Update on cerebral monitoring and protective methods].

Clamping ischaemia is responsible for the 20-30% of the neurological complications during carotid surgery. It is impossible at present to determine preoperatively for certainty the patients who are at risk and the ones who are not at risk for clamping ischemia. Intraoperative monitoring is mandatory in all the cases to point out cerebral ischemia and to prevent neurological deficit with an adequate brain protection. Methods used to predict brain ischaemia include local anesthesia, EEG, SEP, stump pressure measurement, transcranial doppler, regional cerebral blood flow measurement and evaluation of venous blood gases from the internal jugular vein. Local anesthesia is a safe and simple method of assessing cerebral ischemia during carotid clamping but has some limits particularly in case of brain ischaemia for the technical difficulties to install an indwelling shunt in an awake and often troubled patient. Moreover the only possibility of cerebral protection under local anesthesia is an increase in systemic blood pressure with a resulting growth in cardiac morbidity and mortality. For these reasons operation should be performed under general anesthesia to assure a better farmacogical brain protection when preoperative evaluation demonstrates a reduction of cerebral vasoreactivity, with a consequent high risk of clamping ischemia. At present EEG is one of the most used technique of cerebral monitoring under general anesthesia with a sensibility and specificity in the diagnosis of brain ischaemia that is about 90%. The best cerebral protection is obtained with a selective shunting. Burst suppression, with high dose thiopentone, has recently demonstrated its reliability alone or in association with an indwelling shunt in patients at high risk for clamping ischaemia. Of course a systematic cerebral protection together with an accurate control of the blood pressure is necessary in all the patients. This behaviour allowed us to obtain good results in the last 500 patients with a morbidity and mortality respectively of 1% and 1.6% with no significant differences between patients who tolerated carotid clamping and those with clamping ischaemia.

Blood Pressure Determination↗