PubMed Health⌕ Search

Biomedical subjects

R Dillon

Publications and source records attributed to R Dillon.

At least 19 recordsLinked to original sources
PubMed2000

A microscale model of bacterial and biofilm dynamics in porous media.

A microscale model for the transport and coupled reaction of microbes and chemicals in an idealized two-dimensional porous media has been developed. This model includes the flow, transport, and bioreaction of nutrients, electron acceptors, and microbial cells in a saturated granular porous media. The fluid and chemicals are represented as a continuum, but the bacterial cells and solid granular particles are represented discretely. Bacterial cells can attach to the particle surfaces or be advected in the bulk fluid. The bacterial cells can also be motile and move preferentially via a run and tumble mechanism toward a chemoattractant. The bacteria consume oxygen and nutrients and alter the profiles of these chemicals. Attachment of bacterial cells to the soil matrix and growth of bacteria can change the local permeability. The coupling of mass transport and bioreaction can produce spatial gradients of nutrients and electron acceptor concentrations. We describe a numerical method for the microscale model, show results of a convergence study, and present example simulations of the model system.

Biofilms↗
PubMed1999

A mathematical model for outgrowth and spatial patterning of the vertebrate limb bud.

A new model for limb development which incorporates both outgrowth due to cell growth and division, and interactions between morphogens produced in the zone of polarizing activity (ZPA) and the apical epidermal ridge (AER) is developed and analysed. The numerically-computed spatio-temporal distributions of these morphogens demonstrate the importance of interaction between the organizing regions in establishing the morphogenetic terrain on which cells reside, and because growth is explicitly incorporated, it is found that the history of a cell's exposure to the morphogens depends heavily on where the cell originates in the early limb bud. Because the biochemical steps between morphogen(s) and gene activation have not been elucidated, there is no biologically-based mechanism for translating the spatio-temporal distributions of morphogens into patterns of gene expression, but several theoretically plausible functions that bridge the gap are suggested. For example it is shown that interpretation functions based on the history of a cell's exposure to the morphogens can qualitatively account for observed patterns of gene expression. The mathematical model and the associated computational algorithms are sufficiently flexible that other schemes for the interactions between morphogens, and their effect on the spatio-temporal pattern of growth and gene expression, can easily be tested. Thus an additional result of this work is a computational tool that can be used to explore the effects of various mutations and experimental interventions on the growth of the limb and the pattern of gene expression. In future work we will extend the model to a three-dimensional representation of the limb and will incorporate a more realistic description of the rheological properties of the tissue mass, which here is treated as a Newtonian fluid.

Animals↗
PubMed1998

Clinical significance of feline heartworm disease.

The clinical signs and diagnostic approach are different in the cat as compared with the dog, which has impaired the veterinarian's ability to detect this parasite in the cat. New techniques and methodologies have enabled the cat owner and veterinarian to recognize this potentially severe disease. Although much is now known about the pathophysiology and biology of this parasite in the cat, the practical application and rapid development of this information to daily practice has led to confusion.

Animals↗
PubMed1997

Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs.

We tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitor therapy prevents volume-overload hypertrophy in dogs with chronic mitral regurgitation (MR). Seven adult mongrel dogs receiving ramipril (R; 10 mg orally, twice/day) for 4 mo were compared with 11 dogs receiving no R (N) for 4 mo after induction of MR. Cine-magnetic resonance imaging demonstrated that left ventricular (LV) mass increased in the R-MR dogs [80 +/- 4 (SE) to 108 +/- 7 g, P < 0.01] and in the N-MR dogs (92 +/- 7 to 112 +/- 8 g, P < 0.001). LV myocyte cell length was greater in the R-MR and N-MR dogs (203 +/- 6 and 177 +/- 10 microns, respectively) than in normal (144 +/- 4 microns, P < 0.05) dogs. There was significant loss of the collagen weave pattern by scanning electron microscopy in both R-MR and N-MR dogs. LV ACE and chymase activities were significantly elevated in R-MR and N-MR compared with normal dogs. LV angiotensin II (ANG II) levels in the R-MR dogs (28 +/- 12 pg/g) were reduced to levels seen in normal dogs (28 +/- 4 pg/g) compared with N-MR dogs (72 +/- 11 pg/g, P < 0.05). Steady-state AT1-receptor mRNA levels decreased 66% in N-MR compared with normal dogs (P < 0.001) and increased 1.5-fold in R-MR compared with normal dogs (P < 0.01). Thus upregulation of the AT1 receptor in the R-MR hearts may provide a mechanism by which normal intracardiac ANG II levels could continue to mediate LV hypertrophy. However, the mechanism of dissolution collagen weave in both N-MR and R-MR hearts may be related to the stretch of volume overload.

Angiotensin II↗
PubMed1995

A microscale model of bacterial swimming, chemotaxis and substrate transport.

In this paper, we introduce a mathematical and computational model at the microscale level of bacterial motility and chemotaxis coupled with the advection and diffusion of a biologically reacting substrate. The hydrodynamic interaction of a small bacterial population is explicitly modelled through the use of discrete representations of individual microbes. We use the immersed boundary method to couple microbial motion and the advection-diffusion of substrate with the full incompressible Navier-Stokes equations. Simulations using a preliminary two-dimensional model are presented, demonstrating the mutual dependence through the fluid media of several swimming bacteria. A run and tumble mechanism is introduced for simulating the chemotaxis of swimming bacteria.

Bacterial Physiological Phenomena↗
PubMed1995

Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation.

The current study was designed to test the hypothesis that intracardiac angiotensin-converting enzyme (ACE) activity, chymase-like activity, and angiotensin (ANG) peptide levels are increased and are positively related to wall stress estimates in response to the chronic low pressure volume overload of mitral regurgitation produced by percutaneous chordal rupture in the dog. Chronic mitral regurgitation (MR) resulted in an increase in left ventricular (LV) end-diastolic volume [59 +/- 11 (SD) to 103 +/- 32 ml, P < 0.001], LV mass (96 +/- 17 to 114 +/- 23 g, P < 0.001), and a decrease in the LV mass-to-end-diastolic volume ratio (1.64 +/- 0.22 to 1.16 +/- 0.23 g/ml, P < 0.001) measured by magnetic resonance imaging. In vitro studies of heart tissue extracts demonstrated that the majority of ANG II-forming activity was from chymase-like activity rather than from ACE activity in five normal (83.5 +/- 7.5 vs. 6.04 +/- 5.2%) and seven MR hearts (86 +/- 3.9 vs. 2.6 +/- 1.7%). ACE activity (1.22 +/- 0.22 vs. 3.55 +/- 0.62 mU/g, P < 0.05) and chymase-like activity (9.42 +/- 4.64 vs. 20.60 +/- 8.41 nmol.g-1.min-1, P < 0.05) were increased in MR compared with normal hearts. ACE activity correlated with the LV mass-to-volume ratio (r = -0.93, P < 0.001) and LV diastolic wall stress ( r = 0.71, P < 0.05); however, chymase-like activity did not correlate with any hemodynamic parameter. ANG II levels were significantly higher in the midwall of the left ventricle in MR hearts than in normal controls (85 +/- 39 vs. 27 +/- 16 pg/g, P < 0.01). Our results demonstrate a positive correlation between LV diastolic wall stress and increased ACE activity with increased ANG II stores, suggesting that mechanical wall stress activated intracardiac ACE. Although chymase accounted for most ANG II formation in vitro in extracts of both normal and MR dog hearts, the significance of this enzyme in vivo remains unclear.

Angiotensin II↗
PubMed1994

Occurrence of Listeria in hot and cold smoked seafood products.

Over a one-year period, 258 samples of smoked fish products were obtained from retail outlets in Newfoundland and processed for Listeria. Of these, 142 were hot smoked and 116 cold smoked, and the samples comprised of nine species of fish. The Canadian FDA listeria isolation protocol consisted of a two-stage enrichment followed by plating on selective isolation media, Oxford, and LPM. An additional selective medium, PALCAM, was also used. Listeria spp. were isolated from 43 of 258 (16.7%) samples processed in all, with hot smoked products yielding 25.4% (36/142) of the isolates, and cold smoked products yielding 6% of the isolates (7/116). Among the nine species tested, cod had the highest rate of Listeria contamination at 46.7%. Of the 43 Listeria spp. isolated, 18 (41.9%) were L. innocua, 13 (30.2%) were L. welshimeri and 12 (27.9%) were L. monocytogenes.

Food Microbiology↗
PubMed1989

A multimedia medical communication link between a radiology department and an emergency department.

The most critical aspect of a radiologist's work is communicating his findings to the attending physician responsible for the patient's care. This is also the part of the process that is least well organized and the most subject to failure. At the University of Ottawa Medical Communications Research Centre we are investigating technical means to improving communications between radiologists and attending physicians. We first introduce the radiology communication service problem and show why it is essentially a multimedia communication problem. We then briefly describe a multimedia communication system designed and implemented by our research team. The multimedia system consists of several work stations linked by the Hospital's local area network (LAN). Each physician work station comprises a Compaq 386/20-Mhz microcomputer with 16 Mbytes of RAM, a 500-Mbyte image disk, and an image memory that drives a 1,000-line monochrome monitor. The images are digitized using a Konica laser-based film digitizer (2430 by 2000 10-bit pixels for a standard chest radiograph). The multimedia file server manager station is built around a PC-AT compatible with a Northern Telecom Meridian SL-1ST digital PBX and a Meridian Mail digital voice messaging system. This last device is used to store voice data and is linked via the PBX to the workstations' digital telephones. A Sytek 6,000 LAN links all work stations to the file server. All data, image, and graphic information is transmitted via this network, while the twisted pair connections linking the digital PBX to the telephone sets are used for transmitting voice data.(ABSTRACT TRUNCATED AT 250 WORDS)

Computer Communication Networks↗
PubMed1989

Context-dependent enhancements for radiological images.

Many techniques have been proposed to enhance radiographic images and each of them may be optimal depending upon the circumstances. However, the problem confronting the radiologist or the physician is which enhancement to use and how to select the parameters when a specific feature is to be emphasized. At the University of Ottawa, our research work is oriented towards automatic context-dependent enhancements. Our approach attempts to match the three phases involved in viewing a radiograph: getting a global impression, analyzing the objects and the local features, and focusing on the image perturbations. In this article, we report on enhancements to support the first two phases in the case of chest radiographs and on the applicability of gray level reversal transformations.

Emergency Service, Hospital↗
PubMed1985

The liver in systemic disease. An innocent bystander.

The role of the liver in maintaining the health and function of other organs is frequently described in pathophysiologic terms. A large volume of information has been gleaned on the biochemistry and physiology of the "primary" hepatic diseases. In the dog, there is a paucity of information about the chemical events essential to the viability of normal liver cells and, more specifically, the mechanisms by which diseases of other organs secondarily affect the liver.

Animals↗
PubMed1979

Marketing by hospitals: myths and realities.

Is marketing by hospitals myth or reality? This article explores five myths of marketing as well as examines the perceptions of hospital administrators concerning the appropriateness of a number of marketing techniques. The opinions of these administrators indicate several opportunities for expanding the usefulness of marketing by hospitals.

Advertising↗
PubMed1979

Cost-based fee-setting for therapeutic consulting services.

A method for developing cost-based dietetic consulting fees is presented which can be applied in hospital in-patient and out-patient departments and in private practice. Limitations and advantages of the method are noted. The advantages outweigh the drawbacks.

Dietetics↗
PubMedDate not supplied

An analysis of the implications of a magnetic field threshold limit value on utility work practices.

This article examines the implications of a 10 gauss (G) occupational threshold limit value (TLV) on the work practices of a utility that must maintain and repair 500 and 230 kV transmission lines. Three work practices are compared: bare-handed work with live lines (the current practice at the example utility), use of hot sticks, and de-energizing lines prior to work. Bare-handed work with live lines leads to occasional exceedances of the 10 G TLV. Use of hot sticks and de-energizing lines eliminate these exceedances, but they do so at a price. Both practices increase the job duration and, as a result, may increase occupational injury risks. The annual costs for the current live-line, bare-handed practice is approximately $175,000. Use of hot sticks increases this annual cost of maintenance and repair by 30 to 55%. De-energizing lines can increase annual costs by $4 million to $14 million, due to the need for adding additional electricity generation during the planned outages. De-energizing lines also increases the risk to service reliability slightly.

Costs and Cost Analysis↗