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Biomedical subjects

R Diwan

Publications and source records attributed to R Diwan.

6 recordsLinked to original sources
PubMed1992

Cellular localization of retinoic acid receptor-gamma expression in normal and neoplastic skin.

Retinoids profoundly affect the normal growth and differentiation of epithelial tissues. Retinoic acid receptor-gamma (RAR-gamma) is a member of a family of retinoid receptors, and has been shown to be expressed almost exclusively in skin. However, little is known about the cellular localization of this receptor in human skin. The authors studied the expression of RAR-gamma in normal skin and human skin tumors by Northern blot analysis and in situ hybridization. RAR-gamma mRNA was detected in normal skin as well as in cultures of neonatal keratinocytes. Using an oligonucleotide specific for the RAR-gamma cDNA isoform 1 (RAR-gamma 1), RAR-gamma 1 mRNA was localized to all layers of the epidermis, the outer root sheath of hair follicles, follicular hair bulbs, eccrine and sebaceous glands. Basal cell carcinoma constitutively expressed gamma-1 mRNA and one of seven squamous cell carcinomas showed loss of gamma-1 mRNA expression, relative to adjacent epithelium. By contrast, normal melanocytic nevi and tumor-associated lymphocytes expressed little or no RAR-gamma mRNA. These results suggest that RAR-gamma 1 may play an important role in the maintenance and differentiation of normal epidermis and skin appendages.

Blotting, Northern↗
PubMed1990

A comparative study between three ethnic groups to derive some standards for maxillary arch dimensions.

A sample of 91 adult Philippinos, 45 males and 46 females, were selected for maxillary arch measurements. The intercanine width (C-C), intermolar width (M-M), molar incisor (M-I) and molar canine (M-C) length were measured. The measurements were compared to previous studies of maxillary arch dimensions for adult male and female Egyptians and Saudi Arabians. The results showed wider (M-M) measurements for the Egyptians than for the Philippinos, who also showed wider (C-C) arch dimensions than the Saudi Arabians.

Adult↗
PubMed1990

Laser therapy in the treatment of congenital vascular abnormalities.

Portwine stains, especially on the face, have serious psychological and emotional impact for affected children. Laser therapy has been the only effective means for treating these lesions. The argon laser has been the mainstay, but more recently the flashlamp-pumped pulsed dye laser has added significantly to the management of portwine stains as well as to the effective treatment of other vascular lesions such as telangiectasias and angiomas.

Adolescent↗
PubMed1989

Secondary intention healing. The primary approach for management of selected wounds.

Secondary intention healing is an ancient and well-established method of wound management. Since the advent of various reconstructive techniques, it is often forgotten as a valuable alternative to immediate surgical reconstruction of wounds. In certain situations the cosmetic and functional results of secondary intention healing are equal to the results of more complex reconstructive surgery. We describe a case in which remarkable results were obtained from spontaneous healing of a facial wound.

Aged↗