Biomedical subjects
R Donde
Publications and source records attributed to R Donde.
Pigmented villonodular synovitis. A follow-up study.
Pigmented villonodular synovitis (PVS) was diagnosed in 25 patients during the period 1950--76. Twenty-two of the patients were re-examined 2--28 years later. Three patients with local affection of tendon sheaths, treated by excision, were all free of symptoms at follow-up. Nineteen patients all with unilateral knee joint affection were divided into two groups according to peroperative findings, 6 localized PVS and 13 diffuse PVS. The 6 patients with localized PVS all had normal knee movement at follow-up, whereas the 13 with diffuse involvement had varying impaired knee mobility.
A double-blind study comparing sulindac with indomethacin in rheumatoid arthritis.
Forty-two patients with definite or classical rheumatoid arthritis were included in a 6-week double-blind study to compare sulindac with indomethacin. Patients were randomly assigned to therapy, either sulindac 100 mg b.i.d. (plus indomethacin placebo) or indomethacin 25 mg t.i.d. (plus sulindac placebo). As required dosage was increased to either sulindac 200 mg b.i.d. or indomethacin 50 mg t.i.d. Efficacy of the two drugs was found to be equal but sulindac was better tolerated than indomethacin.
Persistent local cutaneous atrophy following corticosteroid injection for tendinitis.
A 21-year-old female, treated with triamcinolone for tendinitis in the oblique muscles of both forearms, developed a skin atrophy, localized around the injection points. The patient was followed over a period of more than five years during which a partial remission of the skin changes was observed. A synopsis covering local use of steroids for various diseases is given.
Plasma and synovial fluid cAMP in patients with rheumatoid arthritis.
cAMP was measured in plasma and synovial fluid from 11 patients suffering from rheumatoid arthritis with a specific protein-binding assay. Plasma and synovial fluid values were 17.0 +/- 6.8 pmol/ml and 8.3 +/- 3.7 pmol/ml, range 5-28 pmol/ml and 5-16 pmol/ml, respectively. No correlation could be established between plasma and synovial fluid levels, plasma and disease activity, or synovial fluid and disease activity, as judged by Lansbury's index. It is concluded that it seems unlikely that synovial fluid cAMP is derived solely from plasma and that no simple relation exists between cAMP in plasma and synovial fluid and total disease activity.
[Transcutaneous nerve-stimulation for relief of pain in patients with rheumatoid arthritis].
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Immune deposits in the dermo-epidermal junction in rheumatoid arthritis.
Skin biopsies from forty patients with rheumatoid arthritis were studied for presence of immune deposits in the dermo-epidermal junction zone. In about half of these unselected patients with classical and definite rheumatoid arthritis, IgM, complement components and fibrinogen antigenic material were found. A positive correlation is demonstrated between immune deposits and the presence of cryoglobulins in serum. The presence of complement components in the skin deposits was found to be clearly related to the clinical activity of the disease, as judged by Lansbury's index.
[Significance of brain lesions for posttraumatic recovery].
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[Comparison between indirect and direct measurements of blood pressure].
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Terminal myocardial infarction. A prospective study.
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Cryoprostatectomy. A follow-up study with special reference to long-term results.
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Traffic casualties. II. Index of severity of accidents: an attempt at definition.
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Traffic casualties. I. Physical and social sequelae: a follow-up of 3000 traffic accidents.
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The primary plasmin inhibitor in rheumatoid synovial fluid.
In 20 consecutive rheumatoid arthritis patients, 14 women and 6 men, age 26--76, average 62 years, the concentration of the recently found "primary plasmin inhibitor" and phase proteins was estimated in plasma and synovial fluid. In 12 patients a complex between the inhibitor and plasmin could be demonstrated by crossed immunoelectrophoresis into immunoglobulins against the primary plasmin inhibitor and immunoglobulin against plasminogen. Only free inhibitor was found in corresponding plasma. All plasminogen present in synovial fluid could be activated to plasmin upon addition of urokinase (24 nM/1). In those patients where enzyme-inhibitor complex in synovial fluid was present, a higher concentration of phase proteins in synovial fluid was found, indicating an increased degree of inflammation despite identical scores in the Lansbury clinical index in the two groups. From these experiments it was concluded that the fibrinolytic capacity in rheumatoid synovial fluid is not decreased. It is suggested that the fibrin-like material in synovial tissue and upon the synovial membrane is a poor substrate for plasmin.