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Biomedical subjects

R Dupuis

Publications and source records attributed to R Dupuis.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Pituitary agenesis in the rat: synthesis of testosterone in fatal testes].

Testosterone radioimmunological assays were made in testes of 19th day fetuses affected with pituitary agenesis. Testosterone was found very reduced but still present, indicating a basic synthesis, independent of hypophyseal stimulation. General apparatus of affected fetuses is grossly normal. Intervention of chorionic gonadotrophin is hypothesized.

Animals↗
PubMed1980

Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia.

The teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, was previously shown. Its prevention by simultaneous administration of cholesterol led to the hypothesis that this action is correlated with the decrease in cholesterol. The present investigation demonstrates that there is an inverse correlation between holoprosencephalic type of malformations and maternal cholesterolemia and that, in Wistar rats, 0.30 g/liter of cholesterolemia is a threshold under which these malformations can be observed.

Abnormalities, Drug-Induced↗
PubMed1979

Teratogenic action and embryo lethality of AY 9944R. Prevention by a hypercholesterolemia-provoking diet.

Embryomortality and teratogenesis provoked by inhibitors of cholesterol synthesis are well demonstrated. Teratogenic action is particularly reflected by holoprosencephalies, but also by uro-genital abnormalities. A hypercholesterolemia-provoking diet has been shown to be completely effective for preventing holoprosencephaly, but only partially so for preventing the uro-genital malformations and fetal mortality. It is thus possible that the two types of abnormalities are governed by different mechanisms. In addition, the diet itself, whose hypercholesterolemic effect is considerable, has certain disadvantages. It seems to have a certain effect on fetal mortality and could be responsible for several uro-genital malformations. This deserves further study.

Abnormalities, Drug-Induced↗
PubMed1979

Interpretation of isolated agenesis of the pituitary.

Cholesterol synthesis inhibitors administered to rats caused more or less complete forms of the holoprosencephalic syndrome, consisting of severe abnormalities of the brain, sense organs and pituitary. The absence of the pituitary was also observed in fetuses without externally visible cephalic abnormalities. These observations suggest that the isolated absence of the pituitary is the lesser form of the holoprosencephalic syndrome. This interpretation is also valid for cases of isolated absence of the pituitary observed in humans.

Abnormalities, Drug-Induced↗
PubMed1977

[Teratogenic action of an inhibitor of cholesterol synthesis in Wistar and Sprague-Dawley rats].

Sprague-Dawley rats are sensitive to the teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, but the dose of inhibitor necessary to induce the same rate of characteristic malformations is twice as large for Sprague-Dawley as for Wistar rats. This variation is probably related to differences in levels of blood cholesterol in the strains and demonstrates a relationship between teratogenicity and metabolic disturbances.

Animals↗
PubMed1970

LSD: no teratogenic action in rats, mice, and hamsters.

Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of body weight per day either at the beginning of gestation or during the period of organogenesis. Examination of the 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses obtained failed to prove any abortifacient, teratogenic, or growth-depressing effects.

Abnormalities, Drug-Induced↗