Biomedical subjects
R E Coifman
Publications and source records attributed to R E Coifman.
Dynamic approach to asthma.
A clinical trial, with historical controls, as of way of conceptualizing labile asthma, which in my experience has proven useful in planning long term ambulatory management, in communicating with and enlisting the support of referring physicians, and in enlisting patient confidence and cooperation in home monitoring and medical management of changes in disease activity is reported.
Peak flowmeter and spirometer mouthpieces as expansion chambers for metered dose aerosols.
Expansion chambers increase effective bronchial delivery of metered dose aerosol asthma medications. A subjective comparison suggests that peak flowmeter and spirometer mouthpiece tubes function effectively as expansion chambers, though less so than a prototype commercial device. Use of mouthpieces as expansion chambers is recommended until improved devices become available.
Management of a potentially harmful health behavior by clinical trial.
A parent had been giving mega-doses of vitamin E to an 8-year-old child with 21-D trisomy for five years in the firmly rooted belief that this therapy was responsible for the child's freedom from constant symptoms of systemic and respiratory infection. The design of an unbiased double-blind clinical trial permitted the parent to reach, on her own, the face-saving conclusion that continuation of this therapy was no longer necessary. Applications of this approach and the underlying nonjudgmental attitude to other potentially harmful health behaviors and practices are discussed.
Contagious fluorescent rash in a 3 1/2-year-old girl.
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The function of irradiated blood elements. I. Limitations on the response to phytohemagglutinin as an indicator of immunocompetence in irradiated lymphocytes.
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A continuous-flow dialysis technique for large volumes.
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Fluorescent antibody studies in human malaria. V. Response of sera from Nigerians to five Plasmodium antigens.
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