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Biomedical subjects

R E Cooper

Publications and source records attributed to R E Cooper.

11 recordsLinked to original sources

Midvastus approach in total knee arthroplasty: a description and a cadaveric study determining the distance of the popliteal artery from the patellar margin of the incision.

Total knee arthroplasty (TKA), one of the most efficacious procedures in orthopedics, requires complete exposure of the knee joint for precise instrumentation. Although most orthopedic surgeons agree that TKA is easily performed using a medial parapatellar approach, a large segment of the patellar blood flow is disrupted by this exposure. The southern or subvastus approach addresses these concerns; however, the procedure has the disadvantage of inadequate exposure in certain patients. A compromise between these two approaches, a midvastus approach, has been described. To decrease potential neurovascular injury, this cadaveric study of the midvastus approach determines the proximity of the incision to the popliteal vascular bundle and addresses the innervation pattern of the vastus medialis oblique. A midvastus arthrotomy was performed on 19 female and 15 male adult cadaveric knees. The midpoint of the superior pole of the patella and the superomedial patellar prominence were marked. After determining the midpoint between the 2 previously mentioned landmarks, an incision was made from that point paralleling the fibers of the vastus medialis oblique medially to the popliteal vascular bundle. The length of the incision was measured three times using calipers; measurements were averaged for each individual specimen, then by gender, and, finally, overall. Ninety-five percent confidence intervals were determined. Differences were assessed by an independent t-test with an alpha level of significance at .05. In addition, the terminal branches of the femoral nerve innervating the vastus medialis oblique were dissected in 5 cadavers. The femoral nerve branched extensively to innervate the vastus medialis oblique. The average distance between the patella and the popliteal vessels was 8.8 +/- 1.4 cm. The average distance in males, 9.5 +/- 1.4 cm, was significantly greater than the distance in females, 8.3 +/- 1.2 cm (P < .02). The distance appeared proportionate to the size of the extremity. The midvastus approach is a viable alternative for primary TKA in selected patients who are not obese and who have not had previous arthrotomy or osteotomy. The average distance (8.8 cm) and corresponding range (6.5 cm minimum to 12.3 cm maximum) are sufficient to suggest a maximal safe distance for sharp dissection of 4.5 cm from the patellar margin in an adult. For additional exposure, the muscle can be safely split further with blunt dissection.

Adult↗

Renal artery bullet embolism.

Bullet embolism is a well-recognized phenomenon. While bullet embolism is not common, renal artery bullet embolism appears to be very rare. We report three cases of bullet embolism to a renal artery. Autopsy findings and bullet types are presented. Such cases are of particular interest to both the medical examiner and the clinician. Failure to consider this phenomenon clinically could lead to infarction of a kidney. A consideration of this phenomenon at autopsy could shorten the dissection time required to retrieve the bullet.

Adult↗

In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads.

The successful treatment of osteomyelitis with commercially prepared gentamicin-polymethylmethacrylate (PMMA) (Septopal) beads and surgical debridement has led to the use of this technique in the United States. However, commercially prepared gentamicin-PMMA beads are not currently available to orthopedic surgeons in the United States. Therefore, these surgeons commonly manufacture their own antibiotic-containing cement beads in the operating room at the time of surgery. There is little data that compare the antibiotic elution characteristics of such preparations to commercially prepared gentamicin-PMMA beads. This study compares the measured amount of antibiotic elution of either gentamicin or tobramycin from laboratory manufactured Zimmer, Simplex, or Palacos beads to commercially prepared gentamicin-PMMA (Septopal) beads. During a 30-day study period, commercially prepared gentamicin-PMMA beads eluted more total antibiotic and maintain higher concentrations than did antibiotic acrylic composites manufactured in the authors' laboratory.

Bacteroides↗

DALE--a system for developing computer-aided biomedical experiments.

The implementation of new computer-aided biomedical experiments usually requires a high level of computing expertise and a significant amount of time. Acquiring this knowledge and devoting the necessary time may result in the inefficient use of a researcher's own particular skills. A number of software aids for laboratory experimentation have been developed, but it is considered that none adequately satisfies the user's requirements. DALE (direct access to laboratory equipment) has been designed as a user-oriented software system, and consists of a menu-based interactive subsystem, with which experiments are defined, and a table-driven interpreter to execute the experiment. Little computing knowledge or development time is required to implement new experiments, and experience has indicated that DALE is a useful tool for biomedical experimentation.

Computers↗

A gradient method of optimizing external-beam radiotherapy treatment plans.

Although a number of methods of treatment optimization by computer have ben proposed, they have received little support. In this paper, an alternative approach is proposed based on the differentials of a treatment evaluation function with respect to wedge angle, incidence angle, entry point, and field weighting. The technique may be used in a batch-oriented computer system, or, by means of a conversational terminal, the therapist can plan a treatment with guidance from the program. Although it can be used to find global optima by a search process, it operates best as a method of improving partially-satisfactory treatments.

Cell Survival↗