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Biomedical subjects

R E Cull

Publications and source records attributed to R E Cull.

10 recordsLinked to original sources
PubMed1992

A comparison of facial grading systems.

There have been several attempts at establishing a grading system to estimate the severity of a facial palsy. This study compares the validity and consistency of all the leading systems. The results indicate that the systems are comparable and overall none had the advantage over the others. Interobserver variation had a significant effect on the consistency of the systems used, but experience of the observer was not a significant factor. The simplest classification studied was the House-Brackman system which is recommended.

Facial Paralysis↗
PubMed1992

Western blotting analysis in patients with MS using human brain vessels as antigen.

Serum samples from patients suffering from multiple sclerosis, other neurological diseases and normal controls were screened by "western blotting" for antibody directed against proteins of human brain vessels purified from a post mortem brain. A small number of sera contained autoantibodies against some of the proteins of the brain vessels, particularly in patients suffering from MS, epilepsy and migraine. The significance of these results is discussed.

Antibody Specificity↗
PubMed1991

Facial weakness. A comparison of clinical and photographic methods of observation.

The search for an internationally acceptable facial grading system has resulted in an assessment of existing methods by several investigators. These studies were based on observations of video film taken of patients with varying degrees of facial malfunction. Although the grading systems were evaluated, the use of videotape has never been compared with clinical examination and its suitability for this type of work is, therefore, unknown. We used nine facial grading systems to compare the results of clinical observation with those of photographic methods of presentation. The latter included videotape, photographic slides, and a combination of the two. The correlation between clinical examination findings and findings of any of the photographic methods was poor, suggesting the need for a standard form of presentation when grading patients. The most consistent results were found with either clinical examination or photographic slides; videotape was the least reliable.

Data Interpretation, Statistical↗
PubMed1991

Neurological disease associated with anticardiolipin antibodies in patients without systemic lupus erythematosus: clinical and immunological features.

Anticardiolipin antibodies (aCL), one of a group of antiphospholipid antibodies which include the lupus anticoagulant (LA), may occur in association with systemic lupus erythematosus (SLE) and are less commonly detected in other diseases. We retrospectively reviewed the clinical and immunological features of 39 consecutive patients with abnormal aCL identified by one laboratory, to examine the spectrum of neurological disease in those patients without SLE. Fourteen patients in this category are described, 6 of whom did not have evidence of LA. All but 1 presented with neurological symptoms. Stroke and migraine dominated the clinical presentation, but many patients had features to suggest the presence of a hypercoagulable state. This study lends support to the concept of a primary antiphospholipid syndrome.

Adult↗
PubMed1990

Migraine occurring for the first time in pregnancy.

Nine patients referred for neurological opinion over a 4 yr. period were identified as having migraine occurring for the first time with pregnancy. The nature of their attacks, results of investigation, the progress of the pregnancy and the prognosis for headache post-partum are presented. One patient had common migraine, the remainder, either classical or complicated attacks. Patients presented at variable stages of pregnancy; four developed complications, including pre-eclamptic toxemia in two. The prognosis for headache during the follow up period of up to 54 months was excellent. The factors influencing migraine in pregnancy are discussed.

Acute Disease↗
PubMed1979

Internal carotid artery occlusion caused by giant cell arteritis.

A case of hemiplegia in a 46 year old woman is described. Total occlusion of the right internal carotid artery was discovered at angiography. Because of persistent elevation of the ESR, and characteristic plasma protein abnormalities, biopsy of the temporal artery was carried out and demonstrated the typical features of giant cell arteritis.

Arterial Occlusive Diseases↗
PubMed1975

Rôle of axonal transport in maintaining central synaptic connections.

Synaptic boutons on the somata of rat hypoglossal neurones have been stained with Zinc Iodide-Osmium, and counted using light microscopy. Two weeks after Silastic cuffs containing colchicine or vinblastine were applied to the hypoglossal nerve, the number of boutons on parent nerve cell bodies was significantly lower than controls. These drugs inhibited retrograde axonal transport of horseradish peroxidase, but did not affect neuromuscular conduction or the number of axons in the nerve trunk. Cuffs containing lignocaine did not affect boutons or axonal transport significantly.

Animals↗