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Biomedical subjects

R E Donevan

Publications and source records attributed to R E Donevan.

9 recordsLinked to original sources
PubMed1983

Eosinophilic pneumonia and atypical mycobacterial infection.

Chronic eosinophilic pneumonia is a relatively uncommon condition associated with fever, malaise, weight loss, dyspnea, and hypoxia. The chest radiograph displays peripheral air-space consolidation, often referred to as the negative of pulmonary edema. The characteristic pathologic findings in the lung include marked accumulation of eosinophils in the alveolar spaces, often with the formation of eosinophilic abscesses. We report the history and pathologic findings in a patient who fit the clinical, radiologic, and pathologic features of chronic eosinophilic pneumonia, but who went on to develop cavitary atypical mycobacterial infection and died. We believe that this case represents an unusual response to an atypical mycobacterial infection.

Aged↗
PubMed1979

Is there a negative correlation between malignancy and respiratory atopy?

A history of respiratory atopy (seasonal hay fever or asthma) was sought among 218 patients with malignancy of endodermal origin (lung, gut, bladder, prostate), 104 patients with mesodermal malignancy (hematological, sarcomas, genitourinary system), 70 patients with ectodermal malignancy (skin and breast) and 303 age and sex matched controls. There was a significantly lower frequency of respiratory allergy in patients with endodermal malignancy when compared with their matched controls (6.4% compared to 13.2%, p less than 0.005). There were no significant differences among any of the other groups. Patients with respiratory atopy appeared to have some degree of protection against developing malignancies of endodermal origin. This may relate to immunologic factors, an inherent difference in the endodermal cell layer in atopic individuals or as yet undertermined factors.

Adult↗
PubMed1976

Miliary tuberculosis presenting with hyponatremia and thrombocytopenia.

A 74-year-old woman with miliary tuberculosis had moderately severe hyponatremia due to inappropriate secretion of antidiuretic hormone (SIADH) and very severe thrombocytopenia without other hematologic abnormalities. She was treated with isoniazid, rifampin, ethambutol, prednisone, vincristine and fluid restriction and recovered completely. The SIADH may have been a response by the posterior pituitary to a decrease in intravascular volume resulting from the extensive pulmonary disease or associated hypoxia, or the tuberculous lung may have released ADH or an ADH-like substance. The thrombocytopenia may have resulted from a direct or indirect toxic effect of infection or, less likely, the tuberculosis may have activated latent idiopathic thrombocytopenic purpura.

Aged↗
PubMed1976

Endobronchial lipoma: two cases and review of the literature.

Endobronchial lipoma is a benign tumour of the large bronchi occurring in middle-aged men. To the 38 successfully treated cases in the English literature a further 2 are added. The symptoms are those of obstructive pneumonitis mimicking bronchogenic carcinoma, and the result of delayed therapy may be bronchiectasis. Treatment includes local resection through a bronchoscope or a bronchotomy incision, or removal, if necessary, of the obstructed lobe or lung at thoracotomy. Smoking may be important in the pathogenesis of this tumour.

Adult↗