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Biomedical subjects

R E Fechner

Publications and source records attributed to R E Fechner.

At least 127 records · Page 7Linked to original sources
PubMed1982

'Endometrial' adenocarcinoma of the prostatic urethra arising in a villous polyp. A light microscopic and immunoperoxidase study.

A 77-year-old man had a papillary neoplasm of the prostatic urethra removed by transurethral resection. Light microscopically, much of the tissue consisted of a benign villous polyp lined by prostatic epithelium. An adenocarcinoma with cells that resembled those of uterine endometrial carcinoma was also present within the villous polyp. Using immunoperoxidase techniques, prostatic acid phosphatase and prostatic-specific antigen were localized in the epithelial cells of both the villous polyp and the adenocarcinoma. To our knowledge, this is the first reported case of adenocarcinoma arising in a urethral polyp. The immunohistochemical findings and the close association of the adenocarcinoma with the prostatic epithelium of the villous polyp provided evidence that so-called endometrial carcinoma of the prostatic utricle is of prostatic epithelial origin rather than müllerian derivation.

Acid Phosphatase↗
PubMed1982

Papillary carcinoma arising from ectopic breast tissue in an axillary lymph node.

A cystic carcinoma was located in an axillary lymph node of a 90-year-old woman. The lymph node also contained cytologically benign mammary ducts and a few small glands that had epithelium cytologically intermediate between the normal epithelium and the neoplastic cells. In a subsequent mastectomy specimen, a small intraductal papillary carcinoma was found, differing cytologically and architectonically from the nodal carcinoma. The nodal carcinoma is considered primary because of its morphologic differences from the mammary lesion, the in situ nature of the mammary tumor, and the transition of benign to atypical epithelium in the nodal inclusions. The occurrence of two tumors is viewed as a field effect.

Aged↗
PubMed1982

Verruca vulgaris of the larynx: a distinctive lesion of probable viral origin confused with verrucous carcinoma.

Two adult males had superficial, keratotic vocal cord lesions. One was diagnosed as verrucous carcinoma, prompting a hemilaryngectomy. The other was interpreted as a squamous papilloma and was treated by local excision. Both patients are disease-free 7 years and 18 months, respectively, following surgery. The histologic features of both lesions are identical to those of cutaneous verruca vulgaris, and immunoperoxidase staining for human papilloma virus was positive in one case. Laryngeal verruca vulgaris has not been previously described and in the past may have been misdiagnosed as verrucous carcinoma, leading to unnecessary surgery. The histologic features of laryngeal verruca vulgaris are presented and its distinction from other cytologically bland, keratotic lesions of the larynx is discussed.

Adult↗
PubMed1982

Amyloid tumor of the breast.

A 55-year-old woman had a solitary mammary amyloid tumor without evidence of a systemic, amyloid-related illness. The tumor produced a palpable, firm mass suspicious for carcinoma. Microscopically, amyloid was found in a periductal and perivascular location. It was seen in the fat as well. A prominent giant cell reaction and chronic inflammatory infiltrate were present.

Amyloid↗
PubMed1981

Pyogenic granuloma of the larynx and trachea. A causal and pathologic misnomer for granulation tissue.

Pyogenic granuloma has a diagnostic, lobular arrangement of capillaries that clearly distinguishes it, histologically, from granulation tissue. Recently, the accurate term, "lobular capillary hemangioma" (LCH), has been introduced to emphasize this characteristic appearance. A review of 639 vascular lesions of the oral cavity, upper respiratory tract, larynx, and trachea yielded 73 LCHs. All were located in nasal or oral mucous membranes. Conversely, every one of 62 vascular lesions from the trachea or larynx consisted of granulation tissue, without evidence of LCHs. There were clinical as well as pathologic differences. The LCHs arose spontaneously, whereas each patient with laryngeal or tracheal granulation tissue had a specific history of trauma. Pyogenic granuloma (ie, LCH) does not occur in the larynx or trachea.

Adolescent↗
PubMed1981

Intermediate filaments in eosinophilic cells of epithelioid sarcoma: a light-microscopic, ultrastructural, and electrophoretic study.

A 41-year-old woman had a mass in her thigh for 5 months. The neoplasm had areas histologically typical of epithelioid sarcoma, but there were also cells with abundant eosinophilic, vacuolated cytoplasm and peripheral, distorted nuclei. These cells resembled signet-ring cells but contained no intracellular mucin. Rather, their cytoplasm was filled with large aggregates of 7-10 nm diameter, nonperiodic filaments, and lipid droplets. Lipid droplets and filaments are common in epithelioid sarcomas, but their presence in sufficient volume to displace the nucleus in a signet-ring fashion has not been described. Electrophoretic analysis of a tumor extract showed that actin was present in insufficient concentration (1-3%) to account for the filamentous aggregates. However, two proteins of 51,000 and 63,000 daltons apparent molecular weight comprised 40-50% of the total protein, suggesting that one or both were the major subunits of the abundant cytoplasmic filaments. Filaments of identical ultrastructural size have been described in a variety of human neoplasms and may be related to a filament characterized in other species and termed vimentin.

Actins↗
PubMed1981

Lobular carcinoma in situ in sclerosing adenosis. A potential source of confusion with invasive carcinoma.

A group of five different patients who had extensive sclerosing adenosis with ductules containing cells characteristic of lobular carcinoma were studied (six breasts in all). Because of the complex arrangement of ductules in sclerosing adenosis, the possibility of an invasive lobular carcinoma was considered in two cases. The distinction between sclerosing adenosis with lobular carcinoma in situ and infiltrating lobular carcinoma rests with the overall architecture of the lesion as seen at low power. Foci of sclerosing adenosis, with or without carcinoma in situ, have dilated ductules peripherally, and narrow ones centrally, whereas infiltrating lobular carcinoma has no overall organization. Because of the diagnosis of lobular carcinoma in situ, extended simple mastectomy was performed in three patients, and as expected, the lymph nodes were free of tumor.

Breast Diseases↗