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Biomedical subjects

R E Frenkel

Publications and source records attributed to R E Frenkel.

11 recordsLinked to original sources

Comparison of the Tono-Pen to the Goldmann applanation tonometer.

Oculab Tono-Pen tonometry was compared with Goldmann applanation tonometry in 142 eyes of 71 patients without corneal problems. Overall we found 63% of the Tono-Pen readings to be within +/- 2 mm Hg of the Goldmann applanation tonometry readings and 77% to be within +/- 3 mm Hg, while 4% were within at least +/- 7 mm Hg difference. The correlation coefficient between the readings of the two instruments was .84. The mean value of the paired differences was 0.81 +/- 3.09 mm Hg overall, -1.78 +/- 1.86 mm Hg in the 4 to 10 mm Hg interval, 0.07 +/- 2.97 mm Hg in the 11 to 20 mm Hg interval, 1.27 +/- 2.62 mm Hg in the 21 to 30 mm Hg interval, and 4.15 +/- 2.28 mm Hg in the 31 to 45 mm Hg interval. We conclude that the Tono-Pen measures intraocular pressure in a manner that corresponds well to the Goldmann tonometer in the 11 to 20 mm Hg interval, and fairly well in the 4 to 10 mm Hg and 21 to 30 mm Hg intervals. It lacks good correspondence in the 31 to 45 mm Hg interval.

Humans

Diagnosis and management of traumatic optic neuropathies.

If a patient has vision immediately following trauma, with subsequent deterioration of visual acuity and/or field, and the presence of a relative afferent pupillary defect, compression of the optic nerve or its vascular supply is very likely. We currently lack a proven optimal treatment, but in the otherwise healthy patient, we suggest an intravenous (IV) loading dose of methylprednisolone 30 mg/kg, and a second 15-mg/kg dose 2 hours after the initial dose, followed by 15 mg/kg every 6 hours. Optic nerve decompression is indicated in this situation when corticosteroids have only a temporary effect, a diminishing one, or none at all. It may also be indicated when there is evidence of a traumatic optic neuropathy with a fractured or narrowed optic foramen or with dislocated bone fragments that directly impinge on the nerve. Optic nerve sheath decompression is indicated in progressive traumatic optic neuropathy when an enlarged fluid-filled sheath has been demonstrated sonographically.

Craniocerebral Trauma

Prevention and management of delayed suprachoroidal hemorrhage after filtration surgery.

We report two new cases of massive delayed nonexpulsive suprachoroidal hemorrhage (DNSH) following a filtering operation in the aphakic eyes of elderly patients with glaucoma. A timely surgical drainage resulted in full recovery of preoperative visual acuity in both of our patients. As we combine our cases with a series of 18 similar cases of others in the literature, the following conclusions emerge. Limited DNSH does not require surgical intervention for a favorable visual outcome. Massive DNSH, however, requires timely and appropriate surgical intervention to achieve a favorable visual outcome and to avoid persistent hypotony. The most effective surgical intervention is drainage of the suprachoroidal hemorrhage and re-formation of the anterior chamber, but without concomitant vitrectomy. In both limited and massive DNSH, the final visual outcome is not determined by the worst vision at the time of DNSH. Some of the known and suspected risk factors of DNSH following filtering surgery are old age, aphakia, postoperative hypotony, a history of vitreous manipulation or complication, general anesthesia, increased venous pressure, use of fluorouracil, and high myopia. In view of these risk factors, we recommend several preventive measures for decreasing the incidence of DNSH following filtering surgery.

Aged

Adult-onset cyclic esotropia and optic atrophy.

A 37-year-old man developed periodic esotropia with 4-day cycles. He was unique because of his age, negative family history for strabismus, bilateral optic atrophy, and absence of light perception in the deviating eye. Adult-onset cyclic esotropia in a blind eye is reported. This afferent defect may lead to secondary changes in the central nervous system, and fusional potential is not necessary for cyclic esotropia to occur.

Adult

Visual loss and intoxication.

The Foster Kennedy Syndrome is very uncommon. The literature cited is often confusing. This paper presents a lucid definition of the syndrome that has contemporary diagnostic value and tenacious historical roots. We attempt to "sort-out" the true Foster Kennedy syndrome from its congeners and discuss the misnomers involved. An illustrative case is presented.

Adult