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Biomedical subjects

R E Girardet

Publications and source records attributed to R E Girardet.

At least 19 recordsLinked to original sources

Acute mycotic aneurysm of the ascending aorta following aortocoronary bypass: successful repair.

Acute mycotic aneurysms of the ascending aorta following aortocoronary bypass are exceedingly rare. To our knowledge, there have been few reports of successful management. The central location of this lesion places it apart from acute or chronic mycotic aneurysms in general and enhances its lethality. The availability of ascending and arch aortography, computerized chest tomography and the techniques of peripheral cardiopulmonary bypass, deep hypothermia and reversible circulatory arrest for prolonged periods of time permit successful management. The purpose of this report is to (1) illustrate such a problem; (2) describe its successful management; (3) review the etiology of mycotic aneurysms, historically and contemporarily; and (4) to differentiate early, acute mycotic aneurysms of the ascending aorta following aortocoronary bypass (usually lethal) from similar late chronic processes (readily reparable).

Acute Disease

Long term physiologic study of thoracic duct lymph and lymphocytes in rat and man.

Techniques for study of thoracic duct lymph and lymphocyte circulations in rats and in man are presented. Radiographic observations, measurements of lymph flow, lymphocyte output, blood lymphocyte level, intra-thoracic pressures and radioactive determinations in the lymph and blood of 51Cr labelled lymphocytes, indicate that the techniques are suitable for long-term study of thoracic duct circulations under physiologic conditions.

Animals

Surgical techniques for long-term studies of thoracic duct circulation in the rat.

Two techniques for cannulation of the thoracic duct in the rat, thoracic duct shunt and thoracic duct side fistula, are described. They give access, for repetitive sampling, to a normal thoracic duct circulation and are suited for study of the circulation under physiologic conditions. The thoracic duct shunt creates, with tubing, a shunt between the caudad and cephalad ends to the cisterna chyli. The exteriorized midportion of the shunt allows observation of the lymph. In the thoracic duct side fistula, the short arm of a T tube is placed within the cisterna and sampling is done via the long arm of the tube. Ten shunts functioned for 8-26 days and 10 side fistulas functioned for 8-30 days. Average lymph flow was 0.044 ml/min (shunts) and 0.042 ml/min (side fistulas). Average thoracic duct lymphocyte output was 1,729,000 cells/min (shunts) and 2,310,000 cells/min (side fistulas). Average blood lymphocyte count was 11,700 cells/mm3 (shunts) and 12,600 cells/mm3 (side fistulas). All parameters remained stable during the period of study. Advantages of those techniques over the Bollman end fistula are presented.

Animals