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Biomedical subjects

R E Haymond

Publications and source records attributed to R E Haymond.

9 recordsLinked to original sources
PubMed1981

gamma-Glutamyltransferase and alkaline phosphatase activities compared in serum of normal children and children with liver disease.

We compared alkaline phosphatase (EC 3.1.3.1) and gamma-glutamyltransferase (EC 2.3.2.2) activities in sera from children with various hepatic diseases with values for normal children. Although values for both enzymes are above normal in essentially the same liver disorders, the latter is much more specific and sensitive. A single value for alkaline phosphatase, measured at any time during childhood or at any stage of liver disease, is extremely difficult to interpret. We suggest that measurement of gamma-glutamyltransferase routinely replace alkaline phosphatase as a screening test and in following patients with obstructive or infiltrative hepatic disorders. We give reliable reference intervals for gamma-glutamyltransferase covering the entire pediatric age group.

Adolescent↗
PubMed1981

Early (chemical) diagnosis of bacterial meningitis--cerebrospinal fluid glucose, lactate, and lactate dehydrogenase compared.

Both lactate and lactate dehydrogenase are more sensitive as early indicators of bacterial meningitis than is glucose, and both appear to help differentiate aseptic from bacterial meningitis. In selected cases, lactate dehydrogenase may be more sensitive than lactate. We also give reference intervals for cerebrospinal fluid cell count, glucose, lactate, and lactate dehydrogenase.

Child↗
PubMed1977

Improved colorimetry of urinary 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid).

Homovanillic acid is an important metabolite of dopamine, and a high proportion of patients with neuroblastoma excrete increased amounts of it in their urine. When this diagnosis is suspected, both homovanillic acid and vanilmandelic acid should be measured, because such a combined measurement reportedly leads to detection of 95% of cases. Although rapid and reliable chemical methods are available for vanilmandelic acid, the same is not true for homovanillic acid. We report here a colorimetric method for homovanillic acid that reasonably fills this void and that can be used in most clinical laboratories. In addition, we present normal values determined for children of various age groups.

Adolescent↗
PubMed1975

Venous serum, capillary serum, and capillary plasma compared for use in determination of lactate dehydrogenase and aspartate aminotransferase activities.

Lactate dehydrogenase and aspartate aminotransferase activities in capillary serum or plasma were significantly greater than in simultaneously assayed venous serum, the greatest differences being between capillary and venous serum. Although some difference is attributable to tissue fluid contributions, platelets seem to account for most of it, with possible small contributions from leukocytes. Capillary tube size and type appear to be important factors. We recommend that when capillary blood is to be used for enzyme assay, it should be processed as plasma.

Aspartate Aminotransferases↗