Gallium-67 imaging in cardiomyopathy.
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Biomedical subjects
Publications and source records attributed to R E Henkin.
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Radionuclide venography in two patients with suspected deep venous disease revealed double channel drainage with cross-pelvic collateral circulation. Contrast inferior venacavograms revealed that one patient had persistent right and left supracardinal veins (double inferior vena cava) and the other had iliac vein occlusion with ascending lumbar collateral circulation. The similarity of radionuclide venographic findings in these two patients emphasizes the importance of contrast venacavography in patients with this appearance on radionuclide venography.
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Since its introduction in 1969, 67Ga has become the most widely employed tumor-scanning agent in nuclear medicine. While 67Ga is far from being the ideal tumor-scanning agent, it remains the best available isotope for this purpose. Gallium-67-citrate has been found to be of value in the staging and reevaluation of lymphomas as well as in detecting the extent and recurrence of lung tumors, breast tumors, malignant melanomas, testicular tumors, brain tumors, and malignant lesions involving the liver. In order to obtain maximum diagnostic value from gallium scanning, several technical factors have to be taken into consideration as well as an understanding of the nature of "false-positive" scans.
Despite its nonspecificity, the thyroid scan remains an important diagnostic aid in the evaluation of the patient with a solitary thyroid nodule. Dual radionuclide thyroid imaging using 99m-Tc pertechnetate and 123-I offers useful information than either alone. The role of complementary diagnostic modalities using ultransonography and thermography looks promising but is as yet unclear.
Experimental venous thrombi were created in 19 dogs, using either thrombin or sodium morrhuate. Eighteen thrombi (95%) were identified by radionuclide venography; however, an 85% false-positive rate was found when nonoperated limbs were studied. The models employed were considered unsuitable for studying the accuracy of labeled particles in diagnosing deep venous thrombosis for the reasons discussed in the text.
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