PubMed Health⌕ Search

Biomedical subjects

R E Jordan

Publications and source records attributed to R E Jordan.

At least 19 recordsLinked to original sources
PubMed1979

Circulating immune complexes in cutaneous vasculitis. Detection with C1q and monoclonal rheumatoid factor.

To investigate the pathogeneic significance of immune complexes in cutaneous vasculitis, 107 patients with various forms of cutaneous vasculitis, including 59 patients with necrotizing (leukocytoclastic) vasculitis (group 1), and 48 patients with lymphocytic vasculitis, or a predominately lymphocytic perivascular infiltrate (group 2), were studied. Immunoglobulins or complement components in cutaneous blood vessels were detected by direct immunofluorescence in high frequency in both groups (91 and 88%, respectively). Using two radioassays for circulating immune complexes, Clq or monoclonal rheumatoid factor (mRF) reactive material was detected in 68% of the patients with necrotizing vasculitis but only 44% of the patients in the lymphocytic-perivascular group. The mRF radioassay was elevated in 58% of the first group of patients and 41% of the patients in group 2, although Clq binding activity was increased in 54% of the patients with necrotizing vasculitis but only in 9% of the patients with a lymphocytic vasculitis or lymphocytic perivascular infiltrate. By using both sucrose density gradient ultracentrifugation and Sepharose 6B gel filtration, the Clq and mRF reactive material detected in some patients with necrotizing vasculitis eluted in high molecular weight fractions that were also anticomplementary. In one patient with necrotizing vasculitis and hepatitis B antigenemia, these heavy molecular weight Clq and mRF reactive fractions contained a two- to three-fold increase in hepatitis B surface antigen when compared with lighter molecular weight fractions. Heavy and light molecular weight mRF reactive material could be detected in selected patients in the lymphocytic-perivascular group as well as in the necrotizing vasculitis group. These studies suggest that cutaneous vasculitis, including acute necrotizing (leukocytoclastic) vasculitis and some forms of lymphocytic vasculitis, and perhaps some diseases characterized by a lymphocytic perivascular infiltrate, may represent cutaneous expressions of immune complex disease.

Antigen-Antibody Complex↗
PubMed1978

Indirect pulp-capping of carious teeth with periapical lesions.

Twenty-four vital teeth with deep carious lesions associated with radiographically demonstrable periapical lesions were treated conservatively by means of the indirect pulp-capping technique. Eleven teeth showed apparent resolution of periapical pathology, an absence of pain, and continued vitality when followed up as long as seven years postoperatively.

Adolescent↗
PubMed1977

Studies on lysyl oxidase of bovine ligamentum nuchae and bovine aorta.

Lysyl oxidase had been purified to near homogeneity from bovine aorta and bovine ligamentum nuchae employing a modification of methods described by Harris et al., and Stassen and his colleagues. The aortic enzyme gives rise to at least three peaks and the ligament enzyme resolves into at least four peaks upon chromatography on DEAE cellulose. The molecular weight of each peak of both enzymes is approximately 30,000 daltons in sodium dodecyl sulfate. The aortic enzyme aggregates to species with molecular weights varying from approximately 60,000 to 1,000,000 daltons upon dialysis out of urea into phosphate-buffered saline. Temperature studies reveal that lysyl oxidase is stable to temperatures as high as 80 degrees C, although the assay optimum is 52 degrees C. Studies in progress suggest the temperature dependency of assay may reflect conformational changes in the elastin substrate.

Amino Acid Oxidoreductases↗
PubMed1977

Restoration of fractured and hypoplastic incisors by the acid etch resin technique: a three-year report.

A total of 724 fractured and hypoplastic incisors were restored using an acid etch resin technique in combination with a newly developed "chamfer shoulder" preparation. The retention rate of the restorations, as observed over a three-year period, was 97.1% for the incisal restorations and 94.4% for the labial veneer restorations. According to evidence reported here, the use of pins for such cases is not recommended.

Acid Etching, Dental↗
PubMed1976

Effect of hydrophobic elastin ligands on the stress-strain properties of elastin fibers.

Alkyl sodium sulfates as well as sodium oleate previously shown to bind to insoluble elastin markedly decrease the tensile strength of fibers of ligament elastin. This effect correlates with the increasing number of carbon atoms in the detergent molecules. These data support previously proposed models which emphasize the importance of hydrophobic bonding to the elastic properties of this connective tissue protein.

Animals↗
PubMed1975

Livedo vasculitis (the vasculitis of atrophie blanche). Immunohistopathologic study.

Hyalinizing segmental vasculitis or livedo vasculitis (atrophie blanche) is a clinical entity with a distinctive immunohistopathologic morphology that can be distinguished from other forms of cutaneous vasculitis by histologic and direct immunofluorescent studies. Our studies showed that immunoglobulins and complement components (C-1g, C-3, and properdin) were localized in diseased vessel walls, suggesting an immune pathogenesis.

Atrophy↗